{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou C"],"funding":["Project of Scientific Innovation Team of Ningbo","Ningbo Social Developmental Key Research","Medical and Health Training Project of Zhejiang Province","Zhejiang Provincial Natural Science Foundation of China","Medical and Health Research Project of Zhejiang Province","the Ningbo Natural Science Foundation","Medical Association Clinical Research Project Funding of Zhejiang Province"],"pagination":["398-409"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6140809"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(4)"],"pubmed_abstract":["DNA methylation plays an important role in the etiology and pathogenesis of head and neck squamous cell carcinoma (HNSCC). The current study aimed to identify aberrantly methylated-differentially expressed genes (DEGs) by a comprehensive bioinformatics analysis. In addition, we screened for DEGs affected by DNA methylation modification and further investigated their prognostic values for HNSCC. We included microarray data of DNA methylation (GSE25093 and GSE33202) and gene expression (GSE23036 and GSE58911) from Gene Expression Omnibus. Aberrantly methylated-DEGs were analyzed with R software. The Cancer Genome Atlas (TCGA) RNA sequencing and DNA methylation (Illumina HumanMethylation450) databases were utilized for validation. In total, 27 aberrantly methylated genes accompanied by altere"],"journal":["Epigenetics"],"pubmed_title":["DNA methylation biomarkers for head and neck squamous cell carcinoma."],"pmcid":["PMC6140809"],"funding_grant_id":["2012A610208","2012C5015","2015B11050","LY16H160005","2015ZYC-A49","2013KYB231","2014PYA017"],"pubmed_authors":["Ye M","Li J","Shen Z","Zhou C","Ye D","Li Q","Ni S","Deng H"],"additional_accession":[]},"is_claimable":false,"name":"DNA methylation biomarkers for head and neck squamous cell carcinoma.","description":"DNA methylation plays an important role in the etiology and pathogenesis of head and neck squamous cell carcinoma (HNSCC). The current study aimed to identify aberrantly methylated-differentially expressed genes (DEGs) by a comprehensive bioinformatics analysis. In addition, we screened for DEGs affected by DNA methylation modification and further investigated their prognostic values for HNSCC. We included microarray data of DNA methylation (GSE25093 and GSE33202) and gene expression (GSE23036 and GSE58911) from Gene Expression Omnibus. Aberrantly methylated-DEGs were analyzed with R software. The Cancer Genome Atlas (TCGA) RNA sequencing and DNA methylation (Illumina HumanMethylation450) databases were utilized for validation. In total, 27 aberrantly methylated genes accompanied by altere","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-04-04T09:26:52.014Z","creation":"2019-08-13T07:01:35Z"},"accession":"S-EPMC6140809","cross_references":{"pubmed":["29927694"],"doi":["10.1080/15592294.2018.1465790"]}}