{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song C"],"funding":["Special Fund of Xinyang Normal University","National Natural Science Foundation of China","Program of National Beef Cattle and Yak Industrial Technology System"],"pagination":["591-604"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6140903"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(6)"],"pubmed_abstract":["Long noncoding RNAs (lncRNAs) are involved in the regulation of skeletal muscle development. In the present study, differentially expressed lncRNAs were identified from RNA-seq data derived from myoblasts and myotubes. We conducted studies to elucidate the function and molecular mechanism of action of Linc-smad7 during skeletal muscle development. Our findings show that Linc-smad7 is upregulated during the early phase of myoblasts differentiation. In in vitro studies, we showed that overexpression of Linc-smad7 promoted the arrest of myoblasts in G1 phase, inhibited DNA replication, and induced myoblast differentiation. Our in vivo studies suggest that Linc-smad7 stimulates skeletal muscle regeneration in cardiotoxin-induced muscle injury. Mechanistically, Linc-smad7 overexpression increas"],"journal":["Epigenetics"],"pubmed_title":["Linc-smad7 promotes myoblast differentiation and muscle regeneration via sponging miR-125b."],"pmcid":["PMC6140903"],"funding_grant_id":["2017001","CARS-38","31772574"],"pubmed_authors":["Dong D","Li H","Yang Z","Yang J","Huang Y","Song C","Ma Y","Chen H","Wang J","Plath M"],"additional_accession":[]},"is_claimable":false,"name":"Linc-smad7 promotes myoblast differentiation and muscle regeneration via sponging miR-125b.","description":"Long noncoding RNAs (lncRNAs) are involved in the regulation of skeletal muscle development. In the present study, differentially expressed lncRNAs were identified from RNA-seq data derived from myoblasts and myotubes. We conducted studies to elucidate the function and molecular mechanism of action of Linc-smad7 during skeletal muscle development. Our findings show that Linc-smad7 is upregulated during the early phase of myoblasts differentiation. In in vitro studies, we showed that overexpression of Linc-smad7 promoted the arrest of myoblasts in G1 phase, inhibited DNA replication, and induced myoblast differentiation. Our in vivo studies suggest that Linc-smad7 stimulates skeletal muscle regeneration in cardiotoxin-induced muscle injury. Mechanistically, Linc-smad7 overexpression increas","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-04-04T09:27:07.882Z","creation":"2019-08-09T07:02:25Z"},"accession":"S-EPMC6140903","cross_references":{"pubmed":["29912619"],"doi":["10.1080/15592294.2018.1481705"]}}