{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Peris L"],"funding":["Agence Nationale de la Recherche","Agence Nationale de la Recherche (French National Research Agency)"],"pagination":["3775"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6141585"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["Emerging evidence indicates that microtubule-associated proteins (MAPs) are implicated in synaptic function; in particular, mice deficient for MAP6 exhibit striking deficits in plasticity and cognition. How MAP6 connects to plasticity mechanisms is unclear. Here, we address the possible role of this protein in dendritic spines. We find that in MAP6-deficient cortical and hippocampal neurons, maintenance of mature spines is impaired, and can be restored by expressing a stretch of the MAP6 sequence called Mc modules. Mc modules directly bind actin filaments and mediate activity-dependent stabilisation of F-actin in dendritic spines, a key event of synaptic plasticity. In vitro, Mc modules enhance actin filament nucleation and promote the formation of stable, highly ordered filament bundles. "],"journal":["Nature communications"],"pubmed_title":["A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines."],"pmcid":["PMC6141585"],"funding_grant_id":["2010- Blanc-120201 CBioS","2011-MALZ-001-0217 MALAAD","2017-CE11-0026 MAMAs"],"pubmed_authors":["Denarier E","Rolland M","Brocard J","Bisbal M","Delphin C","Andrieux A","Arnal I","Goldberg Y","Deloulme JC","Blanchoin L","Peris L","Bosc C","Gory-Faure S","Lante F","Buisson A","Saoudi Y","Sebastien M","Jonckheere J","Martinez-Hernandez J","Guerin C"],"additional_accession":[]},"is_claimable":false,"name":"A key function for microtubule-associated-protein 6 in activity-dependent stabilisation of actin filaments in dendritic spines.","description":"Emerging evidence indicates that microtubule-associated proteins (MAPs) are implicated in synaptic function; in particular, mice deficient for MAP6 exhibit striking deficits in plasticity and cognition. How MAP6 connects to plasticity mechanisms is unclear. Here, we address the possible role of this protein in dendritic spines. We find that in MAP6-deficient cortical and hippocampal neurons, maintenance of mature spines is impaired, and can be restored by expressing a stretch of the MAP6 sequence called Mc modules. Mc modules directly bind actin filaments and mediate activity-dependent stabilisation of F-actin in dendritic spines, a key event of synaptic plasticity. In vitro, Mc modules enhance actin filament nucleation and promote the formation of stable, highly ordered filament bundles. ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Sep","modification":"2026-05-02T09:30:58.01Z","creation":"2019-03-26T23:56:47Z"},"accession":"S-EPMC6141585","cross_references":{"pubmed":["30224655"],"doi":["10.1038/s41467-018-05869-z"]}}