{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Brunkard JO"],"funding":["Agricultural Research Service","National Institutes of Health","NIH HHS"],"pagination":["1333"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6143672"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["The cytosolic RNA exosome, a 3'→5' exoribonuclease complex, contributes to mRNA degradation in eukaryotes, limiting the accumulation of poorly-translated, improperly translated, or aberrant mRNA species. Disruption of cytosolic RNA exosome activity allows aberrant RNA species to accumulate, which can then be detected by host antiviral immune systems as a signature of pathogen infection, activating antiviral defenses. SKI7 is a critical component of the cytosolic RNA exosome in yeast, bridging the catalytic exoribonuclease core with the SKI2/SKI3/SKI8 adaptor complex that guides aberrant RNA substrates into the exosome. The ortholog of <i>SKI7</i> was only recently identified in humans as an alternative splice form of the <i>HBS1</i> gene, which encodes a decoding factor translational GTPas"],"journal":["Frontiers in plant science"],"pubmed_title":["A Two-Headed Monster to Avert Disaster: HBS1/SKI7 Is Alternatively Spliced to Build Eukaryotic RNA Surveillance Complexes."],"pmcid":["PMC6143672"],"funding_grant_id":["5-DP5-OD023072","DP5 OD023072","2030-22000-009-00D"],"pubmed_authors":["Brunkard JO","Baker B"],"additional_accession":[]},"is_claimable":false,"name":"A Two-Headed Monster to Avert Disaster: HBS1/SKI7 Is Alternatively Spliced to Build Eukaryotic RNA Surveillance Complexes.","description":"The cytosolic RNA exosome, a 3'→5' exoribonuclease complex, contributes to mRNA degradation in eukaryotes, limiting the accumulation of poorly-translated, improperly translated, or aberrant mRNA species. Disruption of cytosolic RNA exosome activity allows aberrant RNA species to accumulate, which can then be detected by host antiviral immune systems as a signature of pathogen infection, activating antiviral defenses. SKI7 is a critical component of the cytosolic RNA exosome in yeast, bridging the catalytic exoribonuclease core with the SKI2/SKI3/SKI8 adaptor complex that guides aberrant RNA substrates into the exosome. The ortholog of <i>SKI7</i> was only recently identified in humans as an alternative splice form of the <i>HBS1</i> gene, which encodes a decoding factor translational GTPas","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2026-04-07T19:53:28.033Z","creation":"2026-04-07T17:20:46.552Z"},"accession":"S-EPMC6143672","cross_references":{"pubmed":["30258456"],"doi":["10.3389/fpls.2018.01333"]}}