biostudies-literatureBrunkard JOAgricultural Research ServiceNational Institutes of HealthNIH HHS1333https://www.ebi.ac.uk/biostudies/studies/S-EPMC6143672biostudies-literatureUnknown9The cytosolic RNA exosome, a 3'→5' exoribonuclease complex, contributes to mRNA degradation in eukaryotes, limiting the accumulation of poorly-translated, improperly translated, or aberrant mRNA species. Disruption of cytosolic RNA exosome activity allows aberrant RNA species to accumulate, which can then be detected by host antiviral immune systems as a signature of pathogen infection, activating antiviral defenses. SKI7 is a critical component of the cytosolic RNA exosome in yeast, bridging the catalytic exoribonuclease core with the SKI2/SKI3/SKI8 adaptor complex that guides aberrant RNA substrates into the exosome. The ortholog of <i>SKI7</i> was only recently identified in humans as an alternative splice form of the <i>HBS1</i> gene, which encodes a decoding factor translational GTPasFrontiers in plant scienceA Two-Headed Monster to Avert Disaster: HBS1/SKI7 Is Alternatively Spliced to Build Eukaryotic RNA Surveillance Complexes.PMC61436725-DP5-OD023072DP5 OD0230722030-22000-009-00DBrunkard JOBaker BfalseA Two-Headed Monster to Avert Disaster: HBS1/SKI7 Is Alternatively Spliced to Build Eukaryotic RNA Surveillance Complexes.The cytosolic RNA exosome, a 3'→5' exoribonuclease complex, contributes to mRNA degradation in eukaryotes, limiting the accumulation of poorly-translated, improperly translated, or aberrant mRNA species. Disruption of cytosolic RNA exosome activity allows aberrant RNA species to accumulate, which can then be detected by host antiviral immune systems as a signature of pathogen infection, activating antiviral defenses. SKI7 is a critical component of the cytosolic RNA exosome in yeast, bridging the catalytic exoribonuclease core with the SKI2/SKI3/SKI8 adaptor complex that guides aberrant RNA substrates into the exosome. The ortholog of <i>SKI7</i> was only recently identified in humans as an alternative splice form of the <i>HBS1</i> gene, which encodes a decoding factor translational GTPas2018-01-01T00:00:00Z20182026-04-07T19:53:28.033Z2026-04-07T17:20:46.552ZS-EPMC61436723025845610.3389/fpls.2018.01333