{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Antoulas AC"],"funding":["Phillip J. Carroll, Jr. Professorship","Center for the Advancement of Science in Space","Max-Planck-Institut für Physik Komplexer Systeme","Brockman Medical Research Foundation","National Institute of Diabetes and Digestive and Kidney Diseases","NIDDK NIH HHS","Joyce Family Foundation","DFG (German Science Foundation)","Peter J. Fluor Family Fund","National Institutes of Health","Sonya and William Carpenter","National Science Foundation"],"pagination":["e0198503"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6145530"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(9)"],"pubmed_abstract":["Circadian rhythmicity, the 24-hour cycle responsive to light and dark, is determined by periodic oscillations in gene transcription. This phenomenon has broad ramifications in physiologic function. Recent work has disclosed more cycles in gene transcription, and to the uncovering of these we apply a novel signal processing methodology known as the pencil method and compare it to conventional parametric, nonparametric, and statistical methods.<h4>Methods</h4>In order to assess periodicity of gene expression over time, we analyzed a database derived from livers of mice entrained to a 12-hour light/12-hour dark cycle. We also analyzed artificially generated signals to identify differences between the pencil decomposition and other alternative methods.<h4>Results</h4>The pencil decomposition r"],"journal":["PloS one"],"pubmed_title":["A novel mathematical method for disclosing oscillations in gene transcription: A comparative study."],"pmcid":["PMC6145530"],"funding_grant_id":["11703170","U24 DK097748","AN-693/1-1","GA-2014-136","HD07857","CCF-1320866"],"pubmed_authors":["York B","Antoulas AC","O'Malley BW","Zhu B","Dacso CC","Zhang Q"],"additional_accession":[]},"is_claimable":false,"name":"A novel mathematical method for disclosing oscillations in gene transcription: A comparative study.","description":"Circadian rhythmicity, the 24-hour cycle responsive to light and dark, is determined by periodic oscillations in gene transcription. This phenomenon has broad ramifications in physiologic function. Recent work has disclosed more cycles in gene transcription, and to the uncovering of these we apply a novel signal processing methodology known as the pencil method and compare it to conventional parametric, nonparametric, and statistical methods.<h4>Methods</h4>In order to assess periodicity of gene expression over time, we analyzed a database derived from livers of mice entrained to a 12-hour light/12-hour dark cycle. We also analyzed artificially generated signals to identify differences between the pencil decomposition and other alternative methods.<h4>Results</h4>The pencil decomposition r","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2026-06-16T03:08:04.594Z","creation":"2025-06-01T00:50:23.425Z"},"accession":"S-EPMC6145530","cross_references":{"pubmed":["30231032"],"doi":["10.1371/journal.pone.0198503"]}}