{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hasanpourghadi M"],"funding":["PPP grant"],"pagination":["e5577"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6147144"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6"],"pubmed_abstract":["Combination Index (CI) analysis suggested that MBIC and doxorubicin synergistically inhibited up to 97% of cell proliferation in ER<sup>+</sup>/PR<sup>+</sup>MCF-7 and triple negative MDA-MB-231 breast cancer cell lines. Moreover, treatment of the breast cancer cells with the combined drugs resulted in lower IC<sub>50</sub> values in contrast to the individual drug treatment. Small noncoding microRNAs (miRNA) may function as non-mutational gene regulators at post-transcriptional level of protein synthesis. In the present study, the effect of the combined treatment of MBIC and doxorubicin on the expression level of several miRNAs including miR-34a, miR-146a, miR-320a and miR-542 were evaluated in MCF-7 and MDA-MB-231 breast cancer cell lines. These miRNAs have the potential to alter the pro"],"journal":["PeerJ"],"pubmed_title":["The role of miRNAs 34a, 146a, 320a and 542 in the synergistic anticancer effects of methyl 2-(5-fluoro-2-hydroxyphenyl)-1H- benzo[d]imidazole-5-carboxylate (MBIC) with doxorubicin in breast cancer cells."],"pmcid":["PMC6147144"],"funding_grant_id":["project number: PG048-2015A"],"pubmed_authors":["Rais Mustafa M","Abdul Majid N","Hasanpourghadi M"],"additional_accession":[]},"is_claimable":false,"name":"The role of miRNAs 34a, 146a, 320a and 542 in the synergistic anticancer effects of methyl 2-(5-fluoro-2-hydroxyphenyl)-1H- benzo[d]imidazole-5-carboxylate (MBIC) with doxorubicin in breast cancer cells.","description":"Combination Index (CI) analysis suggested that MBIC and doxorubicin synergistically inhibited up to 97% of cell proliferation in ER<sup>+</sup>/PR<sup>+</sup>MCF-7 and triple negative MDA-MB-231 breast cancer cell lines. Moreover, treatment of the breast cancer cells with the combined drugs resulted in lower IC<sub>50</sub> values in contrast to the individual drug treatment. Small noncoding microRNAs (miRNA) may function as non-mutational gene regulators at post-transcriptional level of protein synthesis. In the present study, the effect of the combined treatment of MBIC and doxorubicin on the expression level of several miRNAs including miR-34a, miR-146a, miR-320a and miR-542 were evaluated in MCF-7 and MDA-MB-231 breast cancer cell lines. These miRNAs have the potential to alter the pro","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2026-06-13T05:46:42.404Z","creation":"2026-06-13T03:09:21.258Z"},"accession":"S-EPMC6147144","cross_references":{"pubmed":["30245930"],"doi":["10.7717/peerj.5577"]}}