{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(9)"],"submitter":["Zhao M"],"pubmed_abstract":["Transcription factor nuclear factor kappa B (NF-κB) regulates cellular responses to environmental cues. Many stimuli induce NF-κB transiently, making time-dependent transcriptional outputs a fundamental feature of NF-κB activation. Here we show that NF-κB target genes have distinct kinetic patterns in activated B lymphoma cells. By combining RELA binding, RNA polymerase II (Pol II) recruitment, and perturbation of NF-κB activation, we demonstrate that kinetic differences amongst early- and late-activated RELA target genes can be understood based on chromatin configuration prior to cell activation and RELA-dependent priming, respectively. We also identified genes that were repressed by RELA activation and others that responded to RELA-activated transcription factors. Cumulatively, our studi"],"journal":["PLoS biology"],"pagination":["e2006347"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6147668"],"repository":["biostudies-literature"],"pubmed_title":["Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation."],"pmcid":["PMC6147668"],"pubmed_authors":["Zhao M","De S","Ji H","Wood WH","Joy J","Zhou W","Becker KG","Sen R"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation.","description":"Transcription factor nuclear factor kappa B (NF-κB) regulates cellular responses to environmental cues. Many stimuli induce NF-κB transiently, making time-dependent transcriptional outputs a fundamental feature of NF-κB activation. Here we show that NF-κB target genes have distinct kinetic patterns in activated B lymphoma cells. By combining RELA binding, RNA polymerase II (Pol II) recruitment, and perturbation of NF-κB activation, we demonstrate that kinetic differences amongst early- and late-activated RELA target genes can be understood based on chromatin configuration prior to cell activation and RELA-dependent priming, respectively. We also identified genes that were repressed by RELA activation and others that responded to RELA-activated transcription factors. Cumulatively, our studi","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Sep","modification":"2026-05-01T18:23:57.381Z","creation":"2019-03-27T00:01:49Z"},"accession":"S-EPMC6147668","cross_references":{"pubmed":["30199532"],"doi":["10.1371/journal.pbio.2006347"]}}