{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu J"],"funding":["CAMS Innovation Fund for Medical Sciences","National Natural Science Foundation of China"],"pagination":["E2226"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6149816"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(12)"],"pubmed_abstract":["In view of the significant neuroprotective effect of <i>Clausena lansium</i>, we continued to separate the <i>n</i>-butanol and the water extracts from the stems of <i>C. lansium</i> in order to find the leading compounds with significant activity. Two new phenolic glycosides, Clausenolside A-B (<b>1</b>-<b>2</b>), one new pair of phenolic enantiomers (<b>3a</b>, <b>3b</b>), and two new monoterpenoids, clausenapene A-B (<b>4</b>-<b>5</b>), together with twelve known analogues (<b>6</b>-<b>17</b>) were isolated from the stems of <i>C. lansium</i>. Compounds <b>1</b>-<b>17</b> were obtained from <i>C. lansium</i> for the first time. Compounds <b>3a</b>, <b>3b</b>, <b>4</b>, <b>16</b>, and <b>17</b> showed strong or moderate potential neuroprotective effects on inhibited PC12 cell injury indu"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Bioactive Compounds from the Stems of Clausena lansium."],"pmcid":["PMC6149816"],"funding_grant_id":["2017-I2M-3-010","NO.81730093","No.21272278"],"pubmed_authors":["Liu J","Du YQ","Li CJ","Chen NH","Zhang DM","Sun H","Li L"],"additional_accession":[]},"is_claimable":false,"name":"Bioactive Compounds from the Stems of Clausena lansium.","description":"In view of the significant neuroprotective effect of <i>Clausena lansium</i>, we continued to separate the <i>n</i>-butanol and the water extracts from the stems of <i>C. lansium</i> in order to find the leading compounds with significant activity. Two new phenolic glycosides, Clausenolside A-B (<b>1</b>-<b>2</b>), one new pair of phenolic enantiomers (<b>3a</b>, <b>3b</b>), and two new monoterpenoids, clausenapene A-B (<b>4</b>-<b>5</b>), together with twelve known analogues (<b>6</b>-<b>17</b>) were isolated from the stems of <i>C. lansium</i>. Compounds <b>1</b>-<b>17</b> were obtained from <i>C. lansium</i> for the first time. Compounds <b>3a</b>, <b>3b</b>, <b>4</b>, <b>16</b>, and <b>17</b> showed strong or moderate potential neuroprotective effects on inhibited PC12 cell injury indu","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Dec","modification":"2026-05-05T23:18:23.497Z","creation":"2019-03-27T00:06:42Z"},"accession":"S-EPMC6149816","cross_references":{"pubmed":["29240703"],"doi":["10.3390/molecules22122226"]}}