biostudies-literatureLiu JCAMS Innovation Fund for Medical SciencesNational Natural Science Foundation of ChinaE2226https://www.ebi.ac.uk/biostudies/studies/S-EPMC6149816biostudies-literatureUnknown22(12)In view of the significant neuroprotective effect of Clausena lansium, we continued to separate the n-butanol and the water extracts from the stems of C. lansium in order to find the leading compounds with significant activity. Two new phenolic glycosides, Clausenolside A-B (1-2), one new pair of phenolic enantiomers (3a, 3b), and two new monoterpenoids, clausenapene A-B (4-5), together with twelve known analogues (6-17) were isolated from the stems of C. lansium. Compounds 1-17 were obtained from C. lansium for the first time. Compounds 3a, 3b, 4, 16, and 17 showed strong or moderate potential neuroprotective effects on inhibited PC12 cell injury induMolecules (Basel, Switzerland)Bioactive Compounds from the Stems of Clausena lansium.PMC61498162017-I2M-3-010NO.81730093No.21272278Liu JDu YQLi CJChen NHZhang DMSun HLi LfalseBioactive Compounds from the Stems of Clausena lansium.In view of the significant neuroprotective effect of Clausena lansium, we continued to separate the n-butanol and the water extracts from the stems of C. lansium in order to find the leading compounds with significant activity. Two new phenolic glycosides, Clausenolside A-B (1-2), one new pair of phenolic enantiomers (3a, 3b), and two new monoterpenoids, clausenapene A-B (4-5), together with twelve known analogues (6-17) were isolated from the stems of C. lansium. Compounds 1-17 were obtained from C. lansium for the first time. Compounds 3a, 3b, 4, 16, and 17 showed strong or moderate potential neuroprotective effects on inhibited PC12 cell injury indu2017-01-01T00:00:00Z2017 Dec2026-05-05T23:18:23.497Z2019-03-27T00:06:42ZS-EPMC61498162924070310.3390/molecules22122226