biostudies-literatureUnknown11Wang J<h4>Background/aim</h4>Glioma is the most common and malignant nervous system tumor and is associated with high-grade malignancy and high recurrence. The mammalian Dachshund1 (DACH1) is a recognized anti-tumor site and has low expression in several malignant tumors, including glioma. We designed and conducted this study to further determine the mechanism of DACH1 in glioma.<h4>Patients and methods</h4>The data collected from specimens of patients with glioma from GSE16011 and REMBRANDT databases were analyzed. The effect of DACH1 on proliferation, migration, and invasion of U87 and U251 cell lines was analyzed in vitro. The symbol targets of the Wnt/β-catenin pathway were also evaluated through Western blot.<h4>Results</h4>DACH1 deficiency was found in glioma tissues, and the DACH1 level wOncoTargets and therapy5853-5863https://www.ebi.ac.uk/biostudies/studies/S-EPMC6149903biostudies-literatureDACH1 inhibits glioma invasion and tumor growth via the Wnt/catenin pathway.PMC6149903Zou YWang QLu XChen MZhang SWang JWu XfalseDACH1 inhibits glioma invasion and tumor growth via the Wnt/catenin pathway.<h4>Background/aim</h4>Glioma is the most common and malignant nervous system tumor and is associated with high-grade malignancy and high recurrence. The mammalian Dachshund1 (DACH1) is a recognized anti-tumor site and has low expression in several malignant tumors, including glioma. We designed and conducted this study to further determine the mechanism of DACH1 in glioma.<h4>Patients and methods</h4>The data collected from specimens of patients with glioma from GSE16011 and REMBRANDT databases were analyzed. The effect of DACH1 on proliferation, migration, and invasion of U87 and U251 cell lines was analyzed in vitro. The symbol targets of the Wnt/β-catenin pathway were also evaluated through Western blot.<h4>Results</h4>DACH1 deficiency was found in glioma tissues, and the DACH1 level w2018-01-01T00:00:00Z20182025-04-19T13:06:08.66Z2019-03-26T23:58:19ZS-EPMC61499033027116810.2147/OTT.S168314