{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["SRLF Trial Group"],"pubmed_abstract":["<h4>Background</h4>Although oversedation has been associated with increased morbidity in ventilated critically ill patients, it is unclear whether prevention of oversedation improves mortality. We aimed to assess 90-day mortality in patients receiving a bundle of interventions to prevent oversedation as compared to usual care.<h4>Methods</h4>In this randomized multicentre trial, all adult patients requiring mechanical ventilation for more than 48 h were included. Two groups were compared: patients managed according to usual sedation practices (control), and patients receiving sedation according to an algorithm which provided a gradual multilevel response to pain, agitation, and ventilator dyssynchrony with no specific target to alter consciousness and no use of sedation scale and promoted "],"journal":["Annals of intensive care"],"pagination":["93"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6150862"],"repository":["biostudies-literature"],"pubmed_title":["Impact of oversedation prevention in ventilated critically ill patients: a randomized trial-the AWARE study."],"pmcid":["PMC6150862"],"pubmed_authors":["Cravoisy-Popovic A","Quentin C","Laterre PF","Annane D","Duguet A","Piagnerelli M","Girault C","Soumer A","Deye N","Leger J","Cleophax C","Hyvernat H","Ena S","da Silva D","Aboab J","Luyt CE","Troche G","Ganster F","Grimaldi D","Plantefeve G","Hicter JF","de Jonghe B","Robert R","Monnet X","Ehrmann S","Rigaud JP","Audoin C","Guerin L","Gros A","Dauriac S","Devos N","Lacherade JC","Jacobs F","Clavier H","Michel P","Bodet-Contentin L","Hernu R","Aissaoui N","Muller G","Cambonie A","Vivier E","Lu Q","Das V","Aliane J","Carteaux G","SRLF Trial Group","Girardie P","Camilatto I","Mira JP","Mercat A","Obbee P","Giraudeau B","Plouvier F","Kimmoun A","Abolfazl MA","Liaudet L","Brouard F","Schenck M","Desmaretz JL","Chergui K","Ricard JD","Donetti L","Azoulay E","Stoclin A","Jacques T","Boulain T","Lambermont B","Picard W","Reignier J","Reuter D","Merat S","Au SM","Hamzaoui O","Vincent F","Legriel S","Baudel JL","Gourdin E","Chouquer R"],"additional_accession":[]},"is_claimable":false,"name":"Impact of oversedation prevention in ventilated critically ill patients: a randomized trial-the AWARE study.","description":"<h4>Background</h4>Although oversedation has been associated with increased morbidity in ventilated critically ill patients, it is unclear whether prevention of oversedation improves mortality. We aimed to assess 90-day mortality in patients receiving a bundle of interventions to prevent oversedation as compared to usual care.<h4>Methods</h4>In this randomized multicentre trial, all adult patients requiring mechanical ventilation for more than 48 h were included. Two groups were compared: patients managed according to usual sedation practices (control), and patients receiving sedation according to an algorithm which provided a gradual multilevel response to pain, agitation, and ventilator dyssynchrony with no specific target to alter consciousness and no use of sedation scale and promoted ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Sep","modification":"2026-05-02T15:53:03.033Z","creation":"2026-04-07T18:14:07.464Z"},"accession":"S-EPMC6150862","cross_references":{"pubmed":["30242747"],"doi":["10.1186/s13613-018-0425-3"]}}