biostudies-literatureUnknown8(1)SRLF Trial Group<h4>Background</h4>Although oversedation has been associated with increased morbidity in ventilated critically ill patients, it is unclear whether prevention of oversedation improves mortality. We aimed to assess 90-day mortality in patients receiving a bundle of interventions to prevent oversedation as compared to usual care.<h4>Methods</h4>In this randomized multicentre trial, all adult patients requiring mechanical ventilation for more than 48 h were included. Two groups were compared: patients managed according to usual sedation practices (control), and patients receiving sedation according to an algorithm which provided a gradual multilevel response to pain, agitation, and ventilator dyssynchrony with no specific target to alter consciousness and no use of sedation scale and promoted Annals of intensive care93https://www.ebi.ac.uk/biostudies/studies/S-EPMC6150862biostudies-literatureImpact of oversedation prevention in ventilated critically ill patients: a randomized trial-the AWARE study.PMC6150862Cravoisy-Popovic AQuentin CLaterre PFAnnane DDuguet APiagnerelli MGirault CSoumer ADeye NLeger JCleophax CHyvernat HEna Sda Silva DAboab JLuyt CETroche GGanster FGrimaldi DPlantefeve GHicter JFde Jonghe BRobert RMonnet XEhrmann SRigaud JPAudoin CGuerin LGros ADauriac SDevos NLacherade JCJacobs FClavier HMichel PBodet-Contentin LHernu RAissaoui NMuller GCambonie AVivier ELu QDas VAliane JCarteaux GSRLF Trial GroupGirardie PCamilatto IMira JPMercat AObbee PGiraudeau BPlouvier FKimmoun AAbolfazl MALiaudet LBrouard FSchenck MDesmaretz JLChergui KRicard JDDonetti LAzoulay EStoclin AJacques TBoulain TLambermont BPicard WReignier JReuter DMerat SAu SMHamzaoui OVincent FLegriel SBaudel JLGourdin EChouquer RfalseImpact of oversedation prevention in ventilated critically ill patients: a randomized trial-the AWARE study.<h4>Background</h4>Although oversedation has been associated with increased morbidity in ventilated critically ill patients, it is unclear whether prevention of oversedation improves mortality. We aimed to assess 90-day mortality in patients receiving a bundle of interventions to prevent oversedation as compared to usual care.<h4>Methods</h4>In this randomized multicentre trial, all adult patients requiring mechanical ventilation for more than 48 h were included. Two groups were compared: patients managed according to usual sedation practices (control), and patients receiving sedation according to an algorithm which provided a gradual multilevel response to pain, agitation, and ventilator dyssynchrony with no specific target to alter consciousness and no use of sedation scale and promoted 2018-01-01T00:00:00Z2018 Sep2026-05-02T15:53:03.033Z2026-04-07T18:14:07.464ZS-EPMC61508623024274710.1186/s13613-018-0425-3