{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(8)"],"submitter":["Pedras MSC"],"pubmed_abstract":["The detoxification of the phytoalexin brassinin to indole-3-carboxaldehyde and <i>S</i>-methyl dithiocarbamate is catalyzed by brassinin oxidase (BOLm), an inducible fungal enzyme produced by the plant pathogen <i>Leptosphaeria maculans</i>. Twenty-six substituted quinolines and isoquinolines are synthesized and evaluated for antifungal activity against <i>L. maculans</i> and inhibition of BOLm. Eleven compounds that inhibit BOLm activity are reported, of which 3-ethyl-6-phenylquinoline displays the highest inhibitory effect. In general, substituted 3-phenylquinolines show significantly higher inhibitory activities than the corresponding 2-phenylquinolines. Overall, these results indicate that the quinoline scaffold is a good lead to design paldoxins (phytoalexin detoxification inhibitors)"],"journal":["Molecules (Basel, Switzerland)"],"pagination":["E1345"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6152025"],"repository":["biostudies-literature"],"pubmed_title":["Inhibitors of the Detoxifying Enzyme of the Phytoalexin Brassinin Based on Quinoline and Isoquinoline Scaffolds."],"pmcid":["PMC6152025"],"pubmed_authors":["Abdoli A","Sarma-Mamillapalle VK","Pedras MSC"],"additional_accession":[]},"is_claimable":false,"name":"Inhibitors of the Detoxifying Enzyme of the Phytoalexin Brassinin Based on Quinoline and Isoquinoline Scaffolds.","description":"The detoxification of the phytoalexin brassinin to indole-3-carboxaldehyde and <i>S</i>-methyl dithiocarbamate is catalyzed by brassinin oxidase (BOLm), an inducible fungal enzyme produced by the plant pathogen <i>Leptosphaeria maculans</i>. Twenty-six substituted quinolines and isoquinolines are synthesized and evaluated for antifungal activity against <i>L. maculans</i> and inhibition of BOLm. Eleven compounds that inhibit BOLm activity are reported, of which 3-ethyl-6-phenylquinoline displays the highest inhibitory effect. In general, substituted 3-phenylquinolines show significantly higher inhibitory activities than the corresponding 2-phenylquinolines. Overall, these results indicate that the quinoline scaffold is a good lead to design paldoxins (phytoalexin detoxification inhibitors)","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Aug","modification":"2026-06-10T09:26:34.922Z","creation":"2026-06-10T03:12:10.609Z"},"accession":"S-EPMC6152025","cross_references":{"pubmed":["28805743"],"doi":["10.3390/molecules22081345"]}}