{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(9)"],"submitter":["Ameku T"],"pubmed_abstract":["Stem cell maintenance is established by neighboring niche cells that promote stem cell self-renewal. However, it is poorly understood how stem cell activity is regulated by systemic, tissue-extrinsic signals in response to environmental cues and changes in physiological status. Here, we show that neuropeptide F (NPF) signaling plays an important role in the pathway regulating mating-induced germline stem cell (GSC) proliferation in the fruit fly Drosophila melanogaster. NPF expressed in enteroendocrine cells (EECs) of the midgut is released in response to the seminal-fluid protein sex peptide (SP) upon mating. This midgut-derived NPF controls mating-induced GSC proliferation via ovarian NPF receptor (NPFR) activity, which modulates bone morphogenetic protein (BMP) signaling levels in GSCs. Our study provides a molecular mechanism that describes how a gut-derived systemic factor couples stem cell behavior to physiological status, such as mating, through interorgan communication."],"journal":["PLoS biology"],"pagination":["e2005004"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6152996"],"repository":["biostudies-literature"],"pubmed_title":["Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner."],"pmcid":["PMC6152996"],"pubmed_authors":["Yoshinari Y","Ameku T","Kondo S","Yoshizaki G","Shimada-Niwa Y","Amezawa K","Texada MJ","Niwa R"],"additional_accession":[]},"is_claimable":false,"name":"Midgut-derived neuropeptide F controls germline stem cell proliferation in a mating-dependent manner.","description":"Stem cell maintenance is established by neighboring niche cells that promote stem cell self-renewal. However, it is poorly understood how stem cell activity is regulated by systemic, tissue-extrinsic signals in response to environmental cues and changes in physiological status. Here, we show that neuropeptide F (NPF) signaling plays an important role in the pathway regulating mating-induced germline stem cell (GSC) proliferation in the fruit fly Drosophila melanogaster. NPF expressed in enteroendocrine cells (EECs) of the midgut is released in response to the seminal-fluid protein sex peptide (SP) upon mating. This midgut-derived NPF controls mating-induced GSC proliferation via ovarian NPF receptor (NPFR) activity, which modulates bone morphogenetic protein (BMP) signaling levels in GSCs. Our study provides a molecular mechanism that describes how a gut-derived systemic factor couples stem cell behavior to physiological status, such as mating, through interorgan communication.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Sep","modification":"2022-02-09T12:34:47.884Z","creation":"2019-03-27T00:02:51Z"},"accession":"S-EPMC6152996","cross_references":{"pubmed":["30248087"],"doi":["10.1371/journal.pbio.2005004"]}}