biostudies-literatureAli AMNIAID NIH HHSBill and Melinda Gates Foundatione02193-17https://www.ebi.ac.uk/biostudies/studies/S-EPMC6153844biostudies-literatureUnknown62(10)Amodiaquine plus artesunate is the recommended antimalarial treatment in many countries where malaria is endemic. However, pediatric doses are largely based on a linear extrapolation from adult doses. We pooled data from previously published studies on the pharmacokinetics of amodiaquine, to optimize the dose across all age groups. Adults and children with uncomplicated malaria received daily weight-based doses of amodiaquine or artesunate-amodiaquine over 3 days. Plasma concentration-time profiles for both the parent drug and the metabolite were characterized using nonlinear mixed-effects modeling. Amodiaquine pharmacokinetics were adequately described by a two-compartment disposition model, with first-order elimination leading to the formation of desethylamodiaquine, which was best descrAntimicrobial agents and chemotherapyPopulation Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing.PMC6153844OPP1099191R01 AI117001Carn GAdjei GOSmith TAAli AMGoka BQTaylor WJones JJAlegre SSOuedraogo EBWWARN Amodiaquine PK Study GroupLwango RChotsiri PBruneel AAubouy AOuedraogo AOgutu BMorgan CCDenti PPinoges LGansane AObonyo CBaudin EHouze PPenny MAFaucher JFBenakis ACammas MRodrigues OPSirima SBPhyo APJullien VAlifrangis MGerman PBertaux LKristensen KAmedome HNosten FClark TDMwesigwa JBranger MDrysdale TSchramm BDorsey GKiechel JRAweeka FHoegberg LCGSundaygar TSinou VDay NPJMcGready RParikh SGuerin PJMazinda CSJuma ETaudon NAshley EAMcGee BDeloron PMassougbodji AComte EDoritchamou JSimpson JASasi PBergstrand MWorkman LParzy DTarning JSugnaux FWin AKMalaika LTMHsi PBarnes KIAnnerberg AKossou HSinghasivanon PValeh PCottrell GKamya MRRijken MJAdeothy ACot MKurtzhals JALSmith RZolia YMKalyango JNStepniewska KRosenthal PJGourmel BWhite NJfalsePopulation Pharmacokinetics of the Antimalarial Amodiaquine: a Pooled Analysis To Optimize Dosing.Amodiaquine plus artesunate is the recommended antimalarial treatment in many countries where malaria is endemic. However, pediatric doses are largely based on a linear extrapolation from adult doses. We pooled data from previously published studies on the pharmacokinetics of amodiaquine, to optimize the dose across all age groups. Adults and children with uncomplicated malaria received daily weight-based doses of amodiaquine or artesunate-amodiaquine over 3 days. Plasma concentration-time profiles for both the parent drug and the metabolite were characterized using nonlinear mixed-effects modeling. Amodiaquine pharmacokinetics were adequately described by a two-compartment disposition model, with first-order elimination leading to the formation of desethylamodiaquine, which was best descr2018-01-01T00:00:00Z2018 Oct2026-06-14T04:20:38.649Z2026-06-14T03:09:12.641ZS-EPMC61538443003803910.1128/AAC.02193-17