{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hopgood H"],"funding":["National Science Foundation"],"pagination":["E696"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6154340"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(5)"],"pubmed_abstract":["Very little is known about enolate addition chemistry under solver-free mechanochemical conditions. In this report, we investigated the ability to selectively form products arising from the primary, secondary, and tertiary enolates under solvent-free conditions. Using potassium tert-butoxide as the base and primary, secondary, and tertiary electrophiles, we were able to generate various enolate addition products including, 1,3,3,3-tetraphenyl-2,2-dimethyl-1-propanone; a molecule we did not observe under traditional solution-based conditions."],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["An Increased Understanding of Enolate Additions under Mechanochemical Conditions."],"pmcid":["PMC6154340"],"funding_grant_id":["1465110"],"pubmed_authors":["Hopgood H","Mack J"],"additional_accession":[]},"is_claimable":false,"name":"An Increased Understanding of Enolate Additions under Mechanochemical Conditions.","description":"Very little is known about enolate addition chemistry under solver-free mechanochemical conditions. In this report, we investigated the ability to selectively form products arising from the primary, secondary, and tertiary enolates under solvent-free conditions. Using potassium tert-butoxide as the base and primary, secondary, and tertiary electrophiles, we were able to generate various enolate addition products including, 1,3,3,3-tetraphenyl-2,2-dimethyl-1-propanone; a molecule we did not observe under traditional solution-based conditions.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Apr","modification":"2024-10-19T05:22:12.808Z","creation":"2019-03-27T00:06:46Z"},"accession":"S-EPMC6154340","cross_references":{"pubmed":["28448450"],"doi":["10.3390/molecules22050696"]}}