biostudies-literatureHopgood HNational Science FoundationE696https://www.ebi.ac.uk/biostudies/studies/S-EPMC6154340biostudies-literatureUnknown22(5)Very little is known about enolate addition chemistry under solver-free mechanochemical conditions. In this report, we investigated the ability to selectively form products arising from the primary, secondary, and tertiary enolates under solvent-free conditions. Using potassium tert-butoxide as the base and primary, secondary, and tertiary electrophiles, we were able to generate various enolate addition products including, 1,3,3,3-tetraphenyl-2,2-dimethyl-1-propanone; a molecule we did not observe under traditional solution-based conditions.Molecules (Basel, Switzerland)An Increased Understanding of Enolate Additions under Mechanochemical Conditions.PMC61543401465110Hopgood HMack JfalseAn Increased Understanding of Enolate Additions under Mechanochemical Conditions.Very little is known about enolate addition chemistry under solver-free mechanochemical conditions. In this report, we investigated the ability to selectively form products arising from the primary, secondary, and tertiary enolates under solvent-free conditions. Using potassium tert-butoxide as the base and primary, secondary, and tertiary electrophiles, we were able to generate various enolate addition products including, 1,3,3,3-tetraphenyl-2,2-dimethyl-1-propanone; a molecule we did not observe under traditional solution-based conditions.2017-01-01T00:00:00Z2017 Apr2024-10-19T05:22:12.808Z2019-03-27T00:06:46ZS-EPMC61543402844845010.3390/molecules22050696