{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fekete B"],"funding":["Országos Tudományos Kutatási Alapprogramok"],"pagination":["E613"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6154686"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(4)"],"pubmed_abstract":["From 2-aminonorbornene hydroxamic acids, a simple and efficient method for the preparation of pyrrolo[1,2-a]pyrimidine enantiomers is reported. The synthesis is based on domino ring-closure followed by microwave-induced retro Diels-Alder (RDA) protocols, where the chirality of the desired products is transferred from norbornene derivatives. The stereochemistry of the synthesized compounds was proven by X-ray crystallography. The absolute configuration of the product is determined by the configuration of the starting amino hydroxamic acid."],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Synthesis of Pyrrolo[1,2-a]pyrimidine Enantiomers via Domino Ring-Closure followed by Retro Diels-Alder Protocol."],"pmcid":["PMC6154686"],"funding_grant_id":["OTKA K-115731"],"pubmed_authors":["Palko M","Fulop F","Fekete B","Haukka M"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of Pyrrolo[1,2-a]pyrimidine Enantiomers via Domino Ring-Closure followed by Retro Diels-Alder Protocol.","description":"From 2-aminonorbornene hydroxamic acids, a simple and efficient method for the preparation of pyrrolo[1,2-a]pyrimidine enantiomers is reported. The synthesis is based on domino ring-closure followed by microwave-induced retro Diels-Alder (RDA) protocols, where the chirality of the desired products is transferred from norbornene derivatives. The stereochemistry of the synthesized compounds was proven by X-ray crystallography. The absolute configuration of the product is determined by the configuration of the starting amino hydroxamic acid.","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Apr","modification":"2024-11-14T21:12:03.433Z","creation":"2019-03-27T00:06:47Z"},"accession":"S-EPMC6154686","cross_references":{"pubmed":["28406463"],"doi":["10.3390/molecules22040613"]}}