biostudies-literatureXu YModern Agro-industry Technology Research System of ChinaShen Lan Young scholars program of Jiangsu University of Science and TechnologyNatural Science Foundation of ChinaSix Talent Peaks Project of Jiangsu ProvinceQing Lan Project of Jiangsu ProvinceE72https://www.ebi.ac.uk/biostudies/studies/S-EPMC6155643biostudies-literatureUnknown22(1)It is widely believed that lipases in ionic liquids (ILs) possess higher enzyme activity, stability and selectivity; however, reaction equilibrium is always limited by product inhibition, and the product is difficult to separate from non-volatile ILs using distillation. To solve this problem, using trialkylphosphine oxide (TOPO) as a complexing agent, a novel biphase of reactive solvent and IL was firstly reported for caffeic acid phenethyl ester (CAPE) production from methyl caffeate (MC) and 2-phenylethanol (PE) catalyzed by lipase <i>via</i> transesterification. The effects of the reaction parameters and their action mechanism were investigated, and the inhibition of CAPE against bacterial wilt pathogen <i>Ralstonia solanacearum</i> was firstly measured. The MC conversion of 98.83% ± 0.Molecules (Basel, Switzerland)Cooperative Reinforcement of Ionic Liquid and Reactive Solvent on Enzymatic Synthesis of Caffeic Acid Phenethyl Ester as an In Vitro Inhibitor of Plant Pathogenic Bacteria.PMC6155643Year of 20152015-NY-018CARS-22Year of 201421206061Liu XWu FAWang CXiao WSheng SWang JXu YfalseCooperative Reinforcement of Ionic Liquid and Reactive Solvent on Enzymatic Synthesis of Caffeic Acid Phenethyl Ester as an In Vitro Inhibitor of Plant Pathogenic Bacteria.It is widely believed that lipases in ionic liquids (ILs) possess higher enzyme activity, stability and selectivity; however, reaction equilibrium is always limited by product inhibition, and the product is difficult to separate from non-volatile ILs using distillation. To solve this problem, using trialkylphosphine oxide (TOPO) as a complexing agent, a novel biphase of reactive solvent and IL was firstly reported for caffeic acid phenethyl ester (CAPE) production from methyl caffeate (MC) and 2-phenylethanol (PE) catalyzed by lipase <i>via</i> transesterification. The effects of the reaction parameters and their action mechanism were investigated, and the inhibition of CAPE against bacterial wilt pathogen <i>Ralstonia solanacearum</i> was firstly measured. The MC conversion of 98.83% ± 0.2017-01-01T00:00:00Z2017 Jan2026-06-07T06:37:18.286Z2025-05-29T22:02:15.476ZS-EPMC61556432804545110.3390/molecules22010072