{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li T"],"funding":["Guangzhou Science &amp; Technology Plan Project","National Basic Research Program of China","Guangdong Provincial Natural Science Foundation of China","Presidents fund of Nanfang Hospital","National Natural Science Foundation of China","Guangdong Provincial medical scientific research Foundation of China","Key Program of National Natural Science Foundation of Guangdong, China","Guangzhou Science & Technology Plan Project"],"pagination":["238"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6156870"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["37(1)"],"pubmed_abstract":["<h4>Background</h4>Aberrant activation of Wnt/β-catenin signaling pathway is considered to be an important issue in progression and metastasis of various human cancers, especially in colorectal cancer (CRC). MiR-452 could activate of Wnt/β-catenin signaling. But the mechanism remains unclear.<h4>Methods</h4>The expression of miR-452 in CRC and normal tissues was detected by real-time quantitative PCR. The effect of miR-452 on CRC growth and invasion was conducted by functional experiments in vitro and in vivo. Bioinformatics and cell luciferase function studies verified the direct regulation of miR-452 on the 3'-UTR of the GSK3β, which leads to the activation of Wnt/β-catenin signaling.<h4>Results</h4>MiR-452 was upregulated in CRC compared with normal tissues and was correlated with clini"],"journal":["Journal of experimental & clinical cancer research : CR"],"pubmed_title":["MiR-452 promotes an aggressive colorectal cancer phenotype by regulating a Wnt/β-catenin positive feedback loop."],"pmcid":["PMC6156870"],"funding_grant_id":["2010B031500012","2015C009","No. 2017A030313707, 2016A030310394, 2017A030313463, 2017A030313643, 2017A030313583, 2017A030310081, 2017A030310117, 2017C1034229, 2016A030310394, 2016A030310392, 2016A030310395, 2015A030306048, 2014A030310134","National Natural Science Foundation of China","201300000056","973 program, 2015CB554002","A2016218"],"pubmed_authors":["He H","Yang M","Zhou W","Liu T","Ye Y","Jiao H","Li X","Deng D","Ding Y","Zhu J","Li T","Wang S","Zheng L","Lai Q","Jian X"],"additional_accession":[]},"is_claimable":false,"name":"MiR-452 promotes an aggressive colorectal cancer phenotype by regulating a Wnt/β-catenin positive feedback loop.","description":"<h4>Background</h4>Aberrant activation of Wnt/β-catenin signaling pathway is considered to be an important issue in progression and metastasis of various human cancers, especially in colorectal cancer (CRC). MiR-452 could activate of Wnt/β-catenin signaling. But the mechanism remains unclear.<h4>Methods</h4>The expression of miR-452 in CRC and normal tissues was detected by real-time quantitative PCR. The effect of miR-452 on CRC growth and invasion was conducted by functional experiments in vitro and in vivo. Bioinformatics and cell luciferase function studies verified the direct regulation of miR-452 on the 3'-UTR of the GSK3β, which leads to the activation of Wnt/β-catenin signaling.<h4>Results</h4>MiR-452 was upregulated in CRC compared with normal tissues and was correlated with clini","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Sep","modification":"2025-04-04T11:20:51.854Z","creation":"2019-03-26T23:57:33Z"},"accession":"S-EPMC6156870","cross_references":{"pubmed":["30253791"],"doi":["10.1186/s13046-018-0879-z"]}}