biostudies-literatureLi TGuangzhou Science &amp; Technology Plan ProjectNational Basic Research Program of ChinaGuangdong Provincial Natural Science Foundation of ChinaPresidents fund of Nanfang HospitalNational Natural Science Foundation of ChinaGuangdong Provincial medical scientific research Foundation of ChinaKey Program of National Natural Science Foundation of Guangdong, ChinaGuangzhou Science & Technology Plan Project238https://www.ebi.ac.uk/biostudies/studies/S-EPMC6156870biostudies-literatureUnknown37(1)<h4>Background</h4>Aberrant activation of Wnt/β-catenin signaling pathway is considered to be an important issue in progression and metastasis of various human cancers, especially in colorectal cancer (CRC). MiR-452 could activate of Wnt/β-catenin signaling. But the mechanism remains unclear.<h4>Methods</h4>The expression of miR-452 in CRC and normal tissues was detected by real-time quantitative PCR. The effect of miR-452 on CRC growth and invasion was conducted by functional experiments in vitro and in vivo. Bioinformatics and cell luciferase function studies verified the direct regulation of miR-452 on the 3'-UTR of the GSK3β, which leads to the activation of Wnt/β-catenin signaling.<h4>Results</h4>MiR-452 was upregulated in CRC compared with normal tissues and was correlated with cliniJournal of experimental & clinical cancer research : CRMiR-452 promotes an aggressive colorectal cancer phenotype by regulating a Wnt/β-catenin positive feedback loop.PMC61568702010B0315000122015C009No. 2017A030313707, 2016A030310394, 2017A030313463, 2017A030313643, 2017A030313583, 2017A030310081, 2017A030310117, 2017C1034229, 2016A030310394, 2016A030310392, 2016A030310395, 2015A030306048, 2014A030310134National Natural Science Foundation of China201300000056973 program, 2015CB554002A2016218He HYang MZhou WLiu TYe YJiao HLi XDeng DDing YZhu JLi TWang SZheng LLai QJian XfalseMiR-452 promotes an aggressive colorectal cancer phenotype by regulating a Wnt/β-catenin positive feedback loop.<h4>Background</h4>Aberrant activation of Wnt/β-catenin signaling pathway is considered to be an important issue in progression and metastasis of various human cancers, especially in colorectal cancer (CRC). MiR-452 could activate of Wnt/β-catenin signaling. But the mechanism remains unclear.<h4>Methods</h4>The expression of miR-452 in CRC and normal tissues was detected by real-time quantitative PCR. The effect of miR-452 on CRC growth and invasion was conducted by functional experiments in vitro and in vivo. Bioinformatics and cell luciferase function studies verified the direct regulation of miR-452 on the 3'-UTR of the GSK3β, which leads to the activation of Wnt/β-catenin signaling.<h4>Results</h4>MiR-452 was upregulated in CRC compared with normal tissues and was correlated with clini2018-01-01T00:00:00Z2018 Sep2025-04-04T11:20:51.854Z2019-03-26T23:57:33ZS-EPMC61568703025379110.1186/s13046-018-0879-z