{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Linnstaedt SD"],"funding":["NHGRI NIH HHS","NIAMS NIH HHS","NIGMS NIH HHS"],"pagination":["8407-8420"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6158694"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["38(39)"],"pubmed_abstract":["Previous studies have shown that common variants of the gene coding for FK506-binding protein 51 (<i>FKBP5</i>), a critical regulator of glucocorticoid sensitivity, affect vulnerability to stress-related disorders. In a previous report, <i>FKBP5</i> rs1360780 was identified as a functional variant because of its effect on gene methylation. Here we report evidence for a novel functional <i>FKBP5</i> allele, rs3800373. This study assessed the association between rs3800373 and post-traumatic chronic pain in 1607 women and men from two ethnically diverse human cohorts. The molecular mechanism through which rs3800373 affects adverse outcomes was established via <i>in silico</i>, <i>in vivo</i>, and <i>in vitro</i> analyses. The rs3800373 minor allele predicted worse adverse outcomes after traum"],"journal":["The Journal of neuroscience : the official journal of the Society for Neuroscience"],"pubmed_title":["A Functional riboSNitch in the 3' Untranslated Region of <i>FKBP5</i> Alters MicroRNA-320a Binding Efficiency and Mediates Vulnerability to Chronic Post-Traumatic Pain."],"pmcid":["PMC6158694"],"funding_grant_id":["R01 AR060852","R01 GM101237","R01 HG008133"],"pubmed_authors":["Domeier R","Lackey L","Kutchko KM","Tsai YH","Parker JS","Hendry PL","Pearson C","Rueckeis CA","Riker KD","Lewandowski C","McLean SA","McCarthy KR","Datner E","Kaushik S","Linnstaedt SD","Laederach A","Kurz MC","O'Neil B"],"additional_accession":[]},"is_claimable":false,"name":"A Functional riboSNitch in the 3' Untranslated Region of <i>FKBP5</i> Alters MicroRNA-320a Binding Efficiency and Mediates Vulnerability to Chronic Post-Traumatic Pain.","description":"Previous studies have shown that common variants of the gene coding for FK506-binding protein 51 (<i>FKBP5</i>), a critical regulator of glucocorticoid sensitivity, affect vulnerability to stress-related disorders. In a previous report, <i>FKBP5</i> rs1360780 was identified as a functional variant because of its effect on gene methylation. Here we report evidence for a novel functional <i>FKBP5</i> allele, rs3800373. This study assessed the association between rs3800373 and post-traumatic chronic pain in 1607 women and men from two ethnically diverse human cohorts. The molecular mechanism through which rs3800373 affects adverse outcomes was established via <i>in silico</i>, <i>in vivo</i>, and <i>in vitro</i> analyses. The rs3800373 minor allele predicted worse adverse outcomes after traum","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Sep","modification":"2025-04-25T17:12:14.035Z","creation":"2019-06-06T20:13:05Z"},"accession":"S-EPMC6158694","cross_references":{"pubmed":["30150364"],"doi":["10.1523/JNEUROSCI.3458-17.2018","10.1523/jneurosci.3458-17.2018"]}}