biostudies-literatureLinnstaedt SDNHGRI NIH HHSNIAMS NIH HHSNIGMS NIH HHS8407-8420https://www.ebi.ac.uk/biostudies/studies/S-EPMC6158694biostudies-literatureUnknown38(39)Previous studies have shown that common variants of the gene coding for FK506-binding protein 51 (<i>FKBP5</i>), a critical regulator of glucocorticoid sensitivity, affect vulnerability to stress-related disorders. In a previous report, <i>FKBP5</i> rs1360780 was identified as a functional variant because of its effect on gene methylation. Here we report evidence for a novel functional <i>FKBP5</i> allele, rs3800373. This study assessed the association between rs3800373 and post-traumatic chronic pain in 1607 women and men from two ethnically diverse human cohorts. The molecular mechanism through which rs3800373 affects adverse outcomes was established via <i>in silico</i>, <i>in vivo</i>, and <i>in vitro</i> analyses. The rs3800373 minor allele predicted worse adverse outcomes after traumThe Journal of neuroscience : the official journal of the Society for NeuroscienceA Functional riboSNitch in the 3' Untranslated Region of <i>FKBP5</i> Alters MicroRNA-320a Binding Efficiency and Mediates Vulnerability to Chronic Post-Traumatic Pain.PMC6158694R01 AR060852R01 GM101237R01 HG008133Domeier RLackey LKutchko KMTsai YHParker JSHendry PLPearson CRueckeis CARiker KDLewandowski CMcLean SAMcCarthy KRDatner EKaushik SLinnstaedt SDLaederach AKurz MCO'Neil BfalseA Functional riboSNitch in the 3' Untranslated Region of <i>FKBP5</i> Alters MicroRNA-320a Binding Efficiency and Mediates Vulnerability to Chronic Post-Traumatic Pain.Previous studies have shown that common variants of the gene coding for FK506-binding protein 51 (<i>FKBP5</i>), a critical regulator of glucocorticoid sensitivity, affect vulnerability to stress-related disorders. In a previous report, <i>FKBP5</i> rs1360780 was identified as a functional variant because of its effect on gene methylation. Here we report evidence for a novel functional <i>FKBP5</i> allele, rs3800373. This study assessed the association between rs3800373 and post-traumatic chronic pain in 1607 women and men from two ethnically diverse human cohorts. The molecular mechanism through which rs3800373 affects adverse outcomes was established via <i>in silico</i>, <i>in vivo</i>, and <i>in vitro</i> analyses. The rs3800373 minor allele predicted worse adverse outcomes after traum2018-01-01T00:00:00Z2018 Sep2025-04-25T17:12:14.035Z2019-06-06T20:13:05ZS-EPMC61586943015036410.1523/JNEUROSCI.3458-17.201810.1523/jneurosci.3458-17.2018