{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2018"],"submitter":["Hester SN"],"funding":["NSE Products, Inc."],"pubmed_abstract":["<h4>Background</h4>Anthocyanins and prebiotics impact overall health and wellness, likely through modulation of the microbiota and the intestinal ecosystem.<h4>Objectives</h4>An 8-week open-label study in male and female volunteers with uncomplicated obesity was designed to study the efficacy of an anthocyanin and prebiotic blend in modulating intestinal microbiota and intestinal inflammation.<h4>Results</h4>After 8 weeks of daily supplementation, participants had a significant decrease in Firmicutes (<i>p</i> < 0.001) and Actinobacteria (<i>p</i> < 0.001) and a significant increase in Bacteroidetes (<i>p</i> < 0.001). Bowel habits were improved as evidenced by reductions in the severity of bloating (<i>p</i> < 0.05), gas (<i>p</i>=0.035), and abdominal pain (<i>p</i>=0.015) as well as significant improvements in stool consistency (<i>p</i> < 0.05). Finally, a nonsignificant decrease in the inflammatory marker fecal calprotectin was seen (<i>p</i>=0.107). The supplement was safe and well tolerated.<h4>Conclusions</h4>The results suggest that regular consumption of the anthocyanin-prebiotic blend positively modulated the intestinal ecosystem and provided insights into the mechanisms of action and its impact on health benefits."],"journal":["Journal of nutrition and metabolism"],"pagination":["7497260"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6158948"],"repository":["biostudies-literature"],"pubmed_title":["Efficacy of an Anthocyanin and Prebiotic Blend on Intestinal Environment in Obese Male and Female Subjects."],"pmcid":["PMC6158948"],"pubmed_authors":["Antony JM","Evans M","Hester SN","Gray R","Mastaloudis A","Wood SM"],"additional_accession":[]},"is_claimable":false,"name":"Efficacy of an Anthocyanin and Prebiotic Blend on Intestinal Environment in Obese Male and Female Subjects.","description":"<h4>Background</h4>Anthocyanins and prebiotics impact overall health and wellness, likely through modulation of the microbiota and the intestinal ecosystem.<h4>Objectives</h4>An 8-week open-label study in male and female volunteers with uncomplicated obesity was designed to study the efficacy of an anthocyanin and prebiotic blend in modulating intestinal microbiota and intestinal inflammation.<h4>Results</h4>After 8 weeks of daily supplementation, participants had a significant decrease in Firmicutes (<i>p</i> < 0.001) and Actinobacteria (<i>p</i> < 0.001) and a significant increase in Bacteroidetes (<i>p</i> < 0.001). Bowel habits were improved as evidenced by reductions in the severity of bloating (<i>p</i> < 0.05), gas (<i>p</i>=0.035), and abdominal pain (<i>p</i>=0.015) as well as significant improvements in stool consistency (<i>p</i> < 0.05). Finally, a nonsignificant decrease in the inflammatory marker fecal calprotectin was seen (<i>p</i>=0.107). The supplement was safe and well tolerated.<h4>Conclusions</h4>The results suggest that regular consumption of the anthocyanin-prebiotic blend positively modulated the intestinal ecosystem and provided insights into the mechanisms of action and its impact on health benefits.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2026-04-07T17:01:25.036Z","creation":"2026-04-07T15:41:30.139Z"},"accession":"S-EPMC6158948","cross_references":{"pubmed":["30302287"],"doi":["10.1155/2018/7497260"]}}