{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang CZ"],"funding":["NCCIH NIH HHS"],"pagination":["S594-S599"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6159225"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(Supplement)"],"pubmed_abstract":["<h4>Introduction</h4>Scutellaria baicalensis is commonly used in Asia as an herbal medicine to treat a variety of ailments, including cancer. Wogonoside, one major constituent of S. baicalensis, can be primarily converted to wogonin through deglycosylation via enteric microbiome metabolism.<h4>Materials and methods</h4>The antiproliferative effects of the glycoside (wogonoside) and its deglycosylated compound (wogonin) on a panel of human cancer cell lines from the most common solid tumors were evaluated using the MTS colorimetric assay. Cell cycle and apoptosis were determined using flow cytometry. Enzymatic activities of caspases were measured, and the interactions of wogonin and caspases were explored by a docking analysis.<h4>Results</h4>Wogonoside did not have obvious antiproliferativ"],"journal":["Journal of cancer research and therapeutics"],"pubmed_title":["Deglycosylation of wogonoside enhances its anticancer potential."],"pmcid":["PMC6159225"],"funding_grant_id":["K01 AT005362","P01 AT004418"],"pubmed_authors":["Zhang CF","Wan JY","Wang CZ","Chen L","Lu F","Yuan CS"],"additional_accession":[]},"is_claimable":false,"name":"Deglycosylation of wogonoside enhances its anticancer potential.","description":"<h4>Introduction</h4>Scutellaria baicalensis is commonly used in Asia as an herbal medicine to treat a variety of ailments, including cancer. Wogonoside, one major constituent of S. baicalensis, can be primarily converted to wogonin through deglycosylation via enteric microbiome metabolism.<h4>Materials and methods</h4>The antiproliferative effects of the glycoside (wogonoside) and its deglycosylated compound (wogonin) on a panel of human cancer cell lines from the most common solid tumors were evaluated using the MTS colorimetric assay. Cell cycle and apoptosis were determined using flow cytometry. Enzymatic activities of caspases were measured, and the interactions of wogonin and caspases were explored by a docking analysis.<h4>Results</h4>Wogonoside did not have obvious antiproliferativ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Sep","modification":"2025-04-18T12:07:15.788Z","creation":"2019-03-26T23:57:34Z"},"accession":"S-EPMC6159225","cross_references":{"pubmed":["30249874"],"doi":["10.4103/0973-1482.183218"]}}