biostudies-literatureUnknown50(9)Chae SThe pathogenesis of type 2 diabetes mellitus (T2DM) is closely associated with mitochondrial functions in insulin-responsive tissues. The mitochondrial proteome, compared with the mitochondrial genome, which only contains 37 genes in humans, can provide more comprehensive information for thousands of mitochondrial proteins regarding T2DM-associated mitochondrial functions. However, T2DM-associated protein signatures in insulin-responsive tissues are still unclear. Here, we performed extensive proteome profiling of mitochondria from skeletal muscles in nine T2DM patients and nine nondiabetic controls. A comparison of the mitochondrial proteomes identified 335 differentially expressed proteins (DEPs) between T2DM and nondiabetic samples. Functional and network analyses of the DEPs showed thaExperimental & molecular medicine1-14https://www.ebi.ac.uk/biostudies/studies/S-EPMC6162255biostudies-literatureA mitochondrial proteome profile indicative of type 2 diabetes mellitus in skeletal muscles.PMC6162255Lim SKim HChae SAhn BYPark KSHa YCChoi SHHwang DKim YHLee SWPark YJKoo KHJang MGJang HCDo Koo YKim SJLee JHfalseA mitochondrial proteome profile indicative of type 2 diabetes mellitus in skeletal muscles.The pathogenesis of type 2 diabetes mellitus (T2DM) is closely associated with mitochondrial functions in insulin-responsive tissues. The mitochondrial proteome, compared with the mitochondrial genome, which only contains 37 genes in humans, can provide more comprehensive information for thousands of mitochondrial proteins regarding T2DM-associated mitochondrial functions. However, T2DM-associated protein signatures in insulin-responsive tissues are still unclear. Here, we performed extensive proteome profiling of mitochondria from skeletal muscles in nine T2DM patients and nine nondiabetic controls. A comparison of the mitochondrial proteomes identified 335 differentially expressed proteins (DEPs) between T2DM and nondiabetic samples. Functional and network analyses of the DEPs showed tha2018-01-01T00:00:00Z2018 Sep2026-04-30T13:29:18.327Z2019-03-27T00:02:53ZS-EPMC61622553026694710.1038/s12276-018-0154-6