{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Folgueira C"],"funding":["Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III)","Ministry of Economy and Competitiveness | Instituto de Salud Carlos III"],"pagination":["14541"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6162323"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["Uroguanylin is a 16 amino acid peptide that constitutes a key component of the gut- brain axis with special relevance in body weight regulation. In childhood and adolescence, periods of life with notable metabolic changes; limited data exist, with measurements of pro-uroguanylin in adolescence but not in prepubertal children. This study investigates pro-uroguanylin circulating levels in children with obesity and its relationship with obesity, sex and pubertal development. We analyzed circulating prouroguanylin levels in 117 children (62) and adolescents (55), including 73 with obesity and 44 with normal weight. The pro-uroguanylin concentration is higher in lean girls during pre-puberty versus lean boys (1111 vs 635, p < 0.001). During puberty, pro-uroguanylin levels are higher in lean mal"],"journal":["Scientific reports"],"pubmed_title":["Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty."],"pmcid":["PMC6162323"],"funding_grant_id":["PI12/01272","pi15/01272"],"pubmed_authors":["Gonzalez-Saenz P","Casanueva FF","Pena-Leon V","Leis R","Vazquez-Cobela R","Ruiz-Pinon M","Dieguez C","Seoane LM","Barja-Fernandez S","Nogueiras R","Castelao C","Folgueira C"],"additional_accession":[]},"is_claimable":false,"name":"Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty.","description":"Uroguanylin is a 16 amino acid peptide that constitutes a key component of the gut- brain axis with special relevance in body weight regulation. In childhood and adolescence, periods of life with notable metabolic changes; limited data exist, with measurements of pro-uroguanylin in adolescence but not in prepubertal children. This study investigates pro-uroguanylin circulating levels in children with obesity and its relationship with obesity, sex and pubertal development. We analyzed circulating prouroguanylin levels in 117 children (62) and adolescents (55), including 73 with obesity and 44 with normal weight. The pro-uroguanylin concentration is higher in lean girls during pre-puberty versus lean boys (1111 vs 635, p < 0.001). During puberty, pro-uroguanylin levels are higher in lean mal","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Sep","modification":"2026-06-06T20:39:24.28Z","creation":"2019-03-26T23:58:33Z"},"accession":"S-EPMC6162323","cross_references":{"pubmed":["30266914"],"doi":["10.1038/s41598-018-32767-7"]}}