biostudies-literaturePotocny AMState of DelawareDivision of ChemistryUniversity of Delaware Research FoundationAmerican Association of University WomenUniversity of DelawareNCRR NIH HHSNational Institute of General Medical SciencesNIGMS NIH HHS10608-10615https://www.ebi.ac.uk/biostudies/studies/S-EPMC6167929biostudies-literatureUnknown57(17)Photodynamic therapy (PDT) represents a minimally invasive and highly localized treatment strategy to ablate tumors with few side effects. In PDT, photosensitizers embedded within tumors are activated by light and undergo intersystem crossing, followed by energy transfer to molecular oxygen, resulting in the production of toxic singlet oxygen (1O2). Previously, we reported a robust, linear tetrapyrrole palladium(II) complex, Pd[DMBil1], characterized by its facile and modular synthesis, broad absorption profile, and efficient 1O2 quantum yield of ΦΔ = 0.8 in organic media. However, the insolubility of this porphyrinoid derivative in aqueous solution prevents its use under biologically relevant conditions. In this work, we report the synthesis of Pd[DMBil1]-PEG750, a water-soluble dimethylbInorganic chemistryPhotochemotherapeutic Properties of a Linear Tetrapyrrole Palladium(II) Complex displaying an Exceptionally High Phototoxicity Index.PMC616792916A00471P30 GM110758CHE1352120P20 GM104316P20GM104316P20 RR017716O'Sullivan RKDay ESPotocny AMRiley RSRosenthal JfalsePhotochemotherapeutic Properties of a Linear Tetrapyrrole Palladium(II) Complex displaying an Exceptionally High Phototoxicity Index.Photodynamic therapy (PDT) represents a minimally invasive and highly localized treatment strategy to ablate tumors with few side effects. In PDT, photosensitizers embedded within tumors are activated by light and undergo intersystem crossing, followed by energy transfer to molecular oxygen, resulting in the production of toxic singlet oxygen (1O2). Previously, we reported a robust, linear tetrapyrrole palladium(II) complex, Pd[DMBil1], characterized by its facile and modular synthesis, broad absorption profile, and efficient 1O2 quantum yield of ΦΔ = 0.8 in organic media. However, the insolubility of this porphyrinoid derivative in aqueous solution prevents its use under biologically relevant conditions. In this work, we report the synthesis of Pd[DMBil1]-PEG750, a water-soluble dimethylb2018-01-01T00:00:00Z2018 Sep2025-04-22T12:56:46.46Z2019-09-07T07:00:25ZS-EPMC61679293013232510.1021/acs.inorgchem.8b01225