{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nalamolu KR"],"funding":["Illinois Neurological Institute, OSF HealthCare Foundation","NIDDK NIH HHS"],"pagination":["153-159"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6169614"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(3)"],"pubmed_abstract":["<h4>Background and purpose</h4>Recent reports from our laboratory demonstrated the post-ischaemic expression profile of various matrix metalloproteinases (MMPs) in rats and the detrimental role of MMP-12 in post-stroke brain damage. We hypothesise that the post-stroke dysregulation of MMPs is similar across species and that genetic deletion of MMP-12 would not affect the post-stroke expression of other MMPs. We tested our hypothesis by determining the pre-ischaemic and post-ischaemic expression profile of MMPs in wild-type and MMP-12 knockout mice.<h4>Methods</h4>Focal cerebral ischaemia was induced in wild-type and MMP-12 knockout mice by middle cerebral artery occlusion procedure by insertion of a monofilament suture. One hour after ischaemia, reperfusion was initiated by removing the mo"],"journal":["Stroke and vascular neurology"],"pubmed_title":["Post-stroke mRNA expression profile of MMPs: effect of genetic deletion of MMP-12."],"pmcid":["PMC6169614"],"funding_grant_id":["R01 DK104031"],"pubmed_authors":["Chelluboina B","Klopfenstein JD","Venkatesh I","Magruder IB","Boini KM","Pinson DM","Veeravalli KK","Fru DN","Mohandass A","Nalamolu KR"],"additional_accession":[]},"is_claimable":false,"name":"Post-stroke mRNA expression profile of MMPs: effect of genetic deletion of MMP-12.","description":"<h4>Background and purpose</h4>Recent reports from our laboratory demonstrated the post-ischaemic expression profile of various matrix metalloproteinases (MMPs) in rats and the detrimental role of MMP-12 in post-stroke brain damage. We hypothesise that the post-stroke dysregulation of MMPs is similar across species and that genetic deletion of MMP-12 would not affect the post-stroke expression of other MMPs. We tested our hypothesis by determining the pre-ischaemic and post-ischaemic expression profile of MMPs in wild-type and MMP-12 knockout mice.<h4>Methods</h4>Focal cerebral ischaemia was induced in wild-type and MMP-12 knockout mice by middle cerebral artery occlusion procedure by insertion of a monofilament suture. One hour after ischaemia, reperfusion was initiated by removing the mo","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Sep","modification":"2025-04-04T19:42:30.154Z","creation":"2021-02-19T19:53:12Z"},"accession":"S-EPMC6169614","cross_references":{"pubmed":["30294471"],"doi":["10.1136/svn-2018-000142"]}}