biostudies-literaturePetry CJAMC-VUMC AllianceNational Institute for Health Research Cambridge Biomedical Research CentreWorld Cancer Research Fund InternationalMedical Research CouncilNational Institute for Health Research (NIHR)European Union Framework 5Newlife Foundation for Disabled ChildrenWellcome TrustMothercare FoundationNovo Nordisk Fonden123https://www.ebi.ac.uk/biostudies/studies/S-EPMC6171563biostudies-literatureUnknown3<b>Background:</b> Although nausea and vomiting are very common in pregnancy, their pathogenesis is poorly understood. We tested the hypothesis that circulating growth and differentiation factor 15 (GDF15) concentrations in early pregnancy, whose gene is implicated in hyperemesis gravidarum, are associated with nausea and vomiting. <b>Methods:</b> Blood samples for the measurement of GDF15 and human chorionic gonadotrophin (hCG) concentrations were obtained early in the second trimester (median 15.1 (interquartile range 14.4-15.7) weeks) of pregnancy from 791 women from the Cambridge Baby Growth Study, a prospective pregnancy and birth cohort. During each trimester participants completed a questionnaire which included questions about nausea, vomiting and antiemetic use. Associations with pWellcome open researchAssociations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: A nested case-control study.PMC6171563RG5460801422NF-SI-0513-101092004/03MC_UU_12012/5MC_UU_12015/2QLK4-1999-014227500001180, MC_UU_12015/207/20100574MC_UU_12012/5/B100574/B/12/ZMC_UU_00014/5Barker PAcerini CLPetry CJOng KKBurling KAPainter RCHughes IADunger DBGoodburn SFAfink GBO'Rahilly SPerry JRBfalseAssociations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: A nested case-control study.<b>Background:</b> Although nausea and vomiting are very common in pregnancy, their pathogenesis is poorly understood. We tested the hypothesis that circulating growth and differentiation factor 15 (GDF15) concentrations in early pregnancy, whose gene is implicated in hyperemesis gravidarum, are associated with nausea and vomiting. <b>Methods:</b> Blood samples for the measurement of GDF15 and human chorionic gonadotrophin (hCG) concentrations were obtained early in the second trimester (median 15.1 (interquartile range 14.4-15.7) weeks) of pregnancy from 791 women from the Cambridge Baby Growth Study, a prospective pregnancy and birth cohort. During each trimester participants completed a questionnaire which included questions about nausea, vomiting and antiemetic use. Associations with p2018-01-01T00:00:00Z20182026-06-14T03:23:08.857Z2019-03-27T00:03:26ZS-EPMC61715633034539010.12688/wellcomeopenres.14818.1