{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Al-Daghri NM"],"pubmed_abstract":["<h4>Objective</h4>Subjects with low vitamin D levels are at risk of cardiometabolic disease. The aim of this study was to identify novel serological markers linking vitamin D status with cardiometabolic profile in non-diabetic adults with obesity.<h4>Methods</h4>For the discovery phase, we used quantitative serum proteomics in sex-matched, age-matched and BMI-matched subjects with obesity [BMI: 25-35 kg/m<sup>2</sup>] and low [25(OH)D < 50 nmol/L] vs. high vitamin D status [25(OH)D > 50 nmol/L] (n = 16). For the validation phase, we performed ELISA in a larger cohort with similar characteristics (n = 179).<h4>Results</h4>We identified 423 and 549 differentially expressed proteins in the high vs. low vitamin D groups of the male and female cohorts, respectively. The small molecule biochemis"],"journal":["Nutrition & diabetes"],"pagination":["54"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6172285"],"repository":["biostudies-literature"],"pubmed_title":["Sex-specific correlation of IGFBP-2 and IGFBP-3 with vitamin D status in adults with obesity: a cross-sectional serum proteomics study."],"pmcid":["PMC6172285"],"pubmed_authors":["Al-Daghri NM","Alokail MS","Teng J","Yakout S","Al-Attas O","Manousopoulou A","Chrousos GP","Garbis SD","Alenad A","Sabico S","Garay-Baquero DJ","Al-Saleh Y","Fotopoulos M"],"additional_accession":[]},"is_claimable":false,"name":"Sex-specific correlation of IGFBP-2 and IGFBP-3 with vitamin D status in adults with obesity: a cross-sectional serum proteomics study.","description":"<h4>Objective</h4>Subjects with low vitamin D levels are at risk of cardiometabolic disease. The aim of this study was to identify novel serological markers linking vitamin D status with cardiometabolic profile in non-diabetic adults with obesity.<h4>Methods</h4>For the discovery phase, we used quantitative serum proteomics in sex-matched, age-matched and BMI-matched subjects with obesity [BMI: 25-35 kg/m<sup>2</sup>] and low [25(OH)D < 50 nmol/L] vs. high vitamin D status [25(OH)D > 50 nmol/L] (n = 16). For the validation phase, we performed ELISA in a larger cohort with similar characteristics (n = 179).<h4>Results</h4>We identified 423 and 549 differentially expressed proteins in the high vs. low vitamin D groups of the male and female cohorts, respectively. The small molecule biochemis","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Oct","modification":"2026-04-17T19:31:00.339Z","creation":"2025-07-28T03:04:12.065Z"},"accession":"S-EPMC6172285","cross_references":{"pubmed":["30287811"],"doi":["10.1038/s41387-018-0063-8"]}}