biostudies-literatureUnknown8(1)Al-Daghri NM<h4>Objective</h4>Subjects with low vitamin D levels are at risk of cardiometabolic disease. The aim of this study was to identify novel serological markers linking vitamin D status with cardiometabolic profile in non-diabetic adults with obesity.<h4>Methods</h4>For the discovery phase, we used quantitative serum proteomics in sex-matched, age-matched and BMI-matched subjects with obesity [BMI: 25-35 kg/m²] and low [25(OH)D < 50 nmol/L] vs. high vitamin D status [25(OH)D > 50 nmol/L] (n = 16). For the validation phase, we performed ELISA in a larger cohort with similar characteristics (n = 179).<h4>Results</h4>We identified 423 and 549 differentially expressed proteins in the high vs. low vitamin D groups of the male and female cohorts, respectively. The small molecule biochemisNutrition & diabetes54https://www.ebi.ac.uk/biostudies/studies/S-EPMC6172285biostudies-literatureSex-specific correlation of IGFBP-2 and IGFBP-3 with vitamin D status in adults with obesity: a cross-sectional serum proteomics study.PMC6172285Al-Daghri NMAlokail MSTeng JYakout SAl-Attas OManousopoulou AChrousos GPGarbis SDAlenad ASabico SGaray-Baquero DJAl-Saleh YFotopoulos MfalseSex-specific correlation of IGFBP-2 and IGFBP-3 with vitamin D status in adults with obesity: a cross-sectional serum proteomics study.<h4>Objective</h4>Subjects with low vitamin D levels are at risk of cardiometabolic disease. The aim of this study was to identify novel serological markers linking vitamin D status with cardiometabolic profile in non-diabetic adults with obesity.<h4>Methods</h4>For the discovery phase, we used quantitative serum proteomics in sex-matched, age-matched and BMI-matched subjects with obesity [BMI: 25-35 kg/m²] and low [25(OH)D < 50 nmol/L] vs. high vitamin D status [25(OH)D > 50 nmol/L] (n = 16). For the validation phase, we performed ELISA in a larger cohort with similar characteristics (n = 179).<h4>Results</h4>We identified 423 and 549 differentially expressed proteins in the high vs. low vitamin D groups of the male and female cohorts, respectively. The small molecule biochemis2018-01-01T00:00:00Z2018 Oct2026-04-17T19:31:00.339Z2025-07-28T03:04:12.065ZS-EPMC61722853028781110.1038/s41387-018-0063-8