{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Murphy N"],"funding":["World Health Organization","Cancer Research UK","Medical Research Council","National Institute for Health Research (NIHR)"],"pagination":["1620-1631"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6175205"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["143(7)"],"pubmed_abstract":["Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (q<sub>values</sub> ) was computed to control for multiple comparisons. All st"],"journal":["International journal of cancer"],"pubmed_title":["A prospective evaluation of plasma polyphenol levels and colon cancer risk."],"pmcid":["PMC6175205"],"funding_grant_id":["001","G1000143","MR/M012190/1","G0401527","NF-SI-0512-10114","25004","MR/N003284/1","14136","16491"],"pubmed_authors":["Tsilidis K","Palli D","Cross AJ","Sacerdote C","Kaaks R","Boeing H","Peeters PH","Freisling H","Khaw KT","Trichopoulou A","Tjonneland A","Boutron-Ruault MC","Murphy N","Kuhn T","Gunter MJ","Zamora-Ros R","Jenab M","Overvad K","Sanchez MJ","Karakatsani A","Tumino R","Grioni S","Vineis P","Panico S","Carbonnel F","Quiros JR","Noh H","Savoye I","Maria Huerta J","Perez-Cornago A","Aleksandrova K","Kyro C","Bueno-de-Mesquita HBA","Barricarte A","Rutegard M","Bradbury KE","Scalbert A","Achaintre D","Altzibar JM","Peppa E","Johansson I"],"additional_accession":[]},"is_claimable":false,"name":"A prospective evaluation of plasma polyphenol levels and colon cancer risk.","description":"Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (q<sub>values</sub> ) was computed to control for multiple comparisons. All st","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Oct","modification":"2026-06-13T05:58:32.701Z","creation":"2026-06-13T03:12:33.581Z"},"accession":"S-EPMC6175205","cross_references":{"pubmed":["29696648"],"doi":["10.1002/ijc.31563"]}}