{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Braubach O"],"funding":["National Research Foundation of Korea (NRF)","NIDCD NIH HHS","NINDS NIH HHS","National Research Foundation of Korea"],"pagination":["14955"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6175855"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["Glomeruli are the functional units of olfactory information processing but little remains known about their individual unit function. This is due to their widespread activation by odor stimuli. We expressed channelrhodopsin-2 in a single olfactory sensory neuron type, and used laser stimulation and simultaneous in vivo calcium imaging to study the responses of a single glomerulus to optogenetic stimulation. Calcium signals in the neuropil of this glomerulus were representative of the sensory input and nearly identical if evoked by intensity-matched odor and laser stimuli. However, significantly fewer glomerular layer interneurons and olfactory bulb output neurons (mitral cells) responded to optogenetic versus odor stimuli, resulting in a small and spatially compact optogenetic glomerular u"],"journal":["Scientific reports"],"pubmed_title":["Sparsened neuronal activity in an optogenetically activated olfactory glomerulus."],"pmcid":["PMC6175855"],"funding_grant_id":["WCI 2009-003","R01 DC005259","U01 NS099691"],"pubmed_authors":["Geiller T","Homma R","Braubach O","Tombaz T","Choi Y","Bozza T","Cohen LB"],"additional_accession":[]},"is_claimable":false,"name":"Sparsened neuronal activity in an optogenetically activated olfactory glomerulus.","description":"Glomeruli are the functional units of olfactory information processing but little remains known about their individual unit function. This is due to their widespread activation by odor stimuli. We expressed channelrhodopsin-2 in a single olfactory sensory neuron type, and used laser stimulation and simultaneous in vivo calcium imaging to study the responses of a single glomerulus to optogenetic stimulation. Calcium signals in the neuropil of this glomerulus were representative of the sensory input and nearly identical if evoked by intensity-matched odor and laser stimuli. However, significantly fewer glomerular layer interneurons and olfactory bulb output neurons (mitral cells) responded to optogenetic versus odor stimuli, resulting in a small and spatially compact optogenetic glomerular u","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Oct","modification":"2025-04-21T21:58:22.035Z","creation":"2019-03-27T00:02:20Z"},"accession":"S-EPMC6175855","cross_references":{"pubmed":["30297851"],"doi":["10.1038/s41598-018-33021-w"]}}