biostudies-literatureUnknown9Cheng L<b>Objectives:</b> Considering sensory stimulation programs (SSP) as a treatment for disorders of consciousness is still debated today. Previous studies investigating its efficacy were affected by various biases among which small sample size and spontaneous recovery. In this study, treatment-related changes were assessed using time-series design in patients with disorders of consciousness (i.e., vegetative state-VS and minimally conscious state-MCS). <b>Methods:</b> A withdrawal design (ABAB) was used. During B phases, patients underwent a SSP (3 days a week, including auditory, visual, tactile, olfactory, and gustatory stimulation). The program was not applied during A phases. To assess behavioral changes, the Coma Recovery Scale-Revised (CRS-R) was administered by an independent rater onFrontiers in neurology826https://www.ebi.ac.uk/biostudies/studies/S-EPMC6176776biostudies-literatureDo Sensory Stimulation Programs Have an Impact on Consciousness Recovery?PMC6176776Cortese DArcuri FCheng LMonti MMWang FRiganello FSchnakers CDi HfalseDo Sensory Stimulation Programs Have an Impact on Consciousness Recovery?<b>Objectives:</b> Considering sensory stimulation programs (SSP) as a treatment for disorders of consciousness is still debated today. Previous studies investigating its efficacy were affected by various biases among which small sample size and spontaneous recovery. In this study, treatment-related changes were assessed using time-series design in patients with disorders of consciousness (i.e., vegetative state-VS and minimally conscious state-MCS). <b>Methods:</b> A withdrawal design (ABAB) was used. During B phases, patients underwent a SSP (3 days a week, including auditory, visual, tactile, olfactory, and gustatory stimulation). The program was not applied during A phases. To assess behavioral changes, the Coma Recovery Scale-Revised (CRS-R) was administered by an independent rater on2018-01-01T00:00:00Z20182025-04-18T16:10:29.567Z2019-03-27T00:03:03ZS-EPMC61767763033378910.3389/fneur.2018.00826