{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sauer CG"],"funding":["National Center for Advancing Translational Sciences","NCATS NIH HHS","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","National Institutes of Health"],"pagination":["641-650"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6176888"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(3)"],"pubmed_abstract":["<h4>Background</h4>Vitamin D regulates intestinal epithelial and immune functions, and vitamin D receptor deficiency increases the severity of murine colitis. Bioavailable 25-hydroxyvitamin D (25(OH)D) is available to target tissues and may be a driver of immune function. The aim is to evaluate the relationship of bioavailable 25(OH)D to the clinical expression of treatment naive pediatric ulcerative colitis (UC).<h4>Methods</h4>The PROTECT (Predicting Response to Standardized Pediatric Colitis Therapy) study enrolled children ≤17 years newly diagnosed with UC. Free and total 25(OH)D were directly measured and 25(OH)D fractions were compared with disease activity measures.<h4>Results</h4>Data were available on 388 subjects, mean age 12.7 years, 49% female, 84% with extensive/pancolitis. Th"],"journal":["Inflammatory bowel diseases"],"pubmed_title":["Free and Bioavailable 25-Hydroxyvitamin D Concentrations are Associated With Disease Activity in Pediatric Patients With Newly Diagnosed Treatment Naive Ulcerative Colitis."],"pmcid":["PMC6176888"],"funding_grant_id":["UL1TR000454","T32 DK007727","UL1 TR002378","UL1 TR000454","P30 DK078392","5U01DK095745"],"pubmed_authors":["Walters T","Davis S","Wang J","Denson LA","Marquis A","Kugathasan S","Baldassano RN","Spada KL","Loop MS","Hyams JS","Patel S","Bonkowski E","Griffiths AM","Venkateswaran S","Baker SS","Rosh J","Boyle B","Keljo DJ","Leleiko NS","Dhawan A","Tangpricha V","Markowitz J","McCall C","Sauer CG","Mack DR","Ziegler TR"],"additional_accession":[]},"is_claimable":false,"name":"Free and Bioavailable 25-Hydroxyvitamin D Concentrations are Associated With Disease Activity in Pediatric Patients With Newly Diagnosed Treatment Naive Ulcerative Colitis.","description":"<h4>Background</h4>Vitamin D regulates intestinal epithelial and immune functions, and vitamin D receptor deficiency increases the severity of murine colitis. Bioavailable 25-hydroxyvitamin D (25(OH)D) is available to target tissues and may be a driver of immune function. The aim is to evaluate the relationship of bioavailable 25(OH)D to the clinical expression of treatment naive pediatric ulcerative colitis (UC).<h4>Methods</h4>The PROTECT (Predicting Response to Standardized Pediatric Colitis Therapy) study enrolled children ≤17 years newly diagnosed with UC. Free and total 25(OH)D were directly measured and 25(OH)D fractions were compared with disease activity measures.<h4>Results</h4>Data were available on 388 subjects, mean age 12.7 years, 49% female, 84% with extensive/pancolitis. Th","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Feb","modification":"2025-04-18T16:10:35.49Z","creation":"2019-08-04T07:59:27Z"},"accession":"S-EPMC6176888","cross_references":{"pubmed":["29462384"],"doi":["10.1093/ibd/izx052"]}}