{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nizet S"],"funding":["Austrian Science Fund FWF"],"pagination":["54-66"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6176897"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>Clinoptilolite is an aluminium silicate of natural origin; the microporous structure and the net negative charge of its crystal lattice allows for adsorption of ions, toxins, inflammatory mediators, and some microorganisms. We generated 2 preparations of purified clinoptilolite, which differed by about 10-fold in particle size, ie, a standard powder (GHC1) and a microparticulate fraction (GHC2) with a size of 3.6 µm and 0.39 µm (d50) respectively. These were examined for their ability to accelerate the recovery of mice from DSS (dextran sulphate sodium)-induced intestinal inflammation.<h4>Methods</h4>Efficacy of clinoptilolite preparations was investigated by administering DSS-treated mice twice daily with 30 mg GHC2 or GHC1 for 5 consecutive days, followed by 5 days of "],"journal":["Inflammatory bowel diseases"],"pubmed_title":["Clinoptilolite in Dextran Sulphate Sodium-Induced Murine Colitis: Efficacy and Safety of a Microparticulate Preparation."],"pmcid":["PMC6176897"],"funding_grant_id":["P 26011"],"pubmed_authors":["Kashofer K","Meisslitzer-Ruppitsch C","Freissmuth M","Abuja PM","Tangermann S","Scheichl L","Fiebich BL","Kenner L","Zatloukal K","Nizet S","Tschegg C","Nagl D","Munoz E","Berger T"],"additional_accession":[]},"is_claimable":false,"name":"Clinoptilolite in Dextran Sulphate Sodium-Induced Murine Colitis: Efficacy and Safety of a Microparticulate Preparation.","description":"<h4>Background</h4>Clinoptilolite is an aluminium silicate of natural origin; the microporous structure and the net negative charge of its crystal lattice allows for adsorption of ions, toxins, inflammatory mediators, and some microorganisms. We generated 2 preparations of purified clinoptilolite, which differed by about 10-fold in particle size, ie, a standard powder (GHC1) and a microparticulate fraction (GHC2) with a size of 3.6 µm and 0.39 µm (d50) respectively. These were examined for their ability to accelerate the recovery of mice from DSS (dextran sulphate sodium)-induced intestinal inflammation.<h4>Methods</h4>Efficacy of clinoptilolite preparations was investigated by administering DSS-treated mice twice daily with 30 mg GHC2 or GHC1 for 5 consecutive days, followed by 5 days of ","dates":{"release":"2017-01-01T00:00:00Z","publication":"2017 Dec","modification":"2026-06-16T05:19:51.335Z","creation":"2019-08-04T07:59:29Z"},"accession":"S-EPMC6176897","cross_references":{"pubmed":["29272495"],"doi":["10.1093/ibd/izx042"]}}