biostudies-literatureNizet SAustrian Science Fund FWF54-66https://www.ebi.ac.uk/biostudies/studies/S-EPMC6176897biostudies-literatureUnknown24(1)<h4>Background</h4>Clinoptilolite is an aluminium silicate of natural origin; the microporous structure and the net negative charge of its crystal lattice allows for adsorption of ions, toxins, inflammatory mediators, and some microorganisms. We generated 2 preparations of purified clinoptilolite, which differed by about 10-fold in particle size, ie, a standard powder (GHC1) and a microparticulate fraction (GHC2) with a size of 3.6 µm and 0.39 µm (d50) respectively. These were examined for their ability to accelerate the recovery of mice from DSS (dextran sulphate sodium)-induced intestinal inflammation.<h4>Methods</h4>Efficacy of clinoptilolite preparations was investigated by administering DSS-treated mice twice daily with 30 mg GHC2 or GHC1 for 5 consecutive days, followed by 5 days of Inflammatory bowel diseasesClinoptilolite in Dextran Sulphate Sodium-Induced Murine Colitis: Efficacy and Safety of a Microparticulate Preparation.PMC6176897P 26011Kashofer KMeisslitzer-Ruppitsch CFreissmuth MAbuja PMTangermann SScheichl LFiebich BLKenner LZatloukal KNizet STschegg CNagl DMunoz EBerger TfalseClinoptilolite in Dextran Sulphate Sodium-Induced Murine Colitis: Efficacy and Safety of a Microparticulate Preparation.<h4>Background</h4>Clinoptilolite is an aluminium silicate of natural origin; the microporous structure and the net negative charge of its crystal lattice allows for adsorption of ions, toxins, inflammatory mediators, and some microorganisms. We generated 2 preparations of purified clinoptilolite, which differed by about 10-fold in particle size, ie, a standard powder (GHC1) and a microparticulate fraction (GHC2) with a size of 3.6 µm and 0.39 µm (d50) respectively. These were examined for their ability to accelerate the recovery of mice from DSS (dextran sulphate sodium)-induced intestinal inflammation.<h4>Methods</h4>Efficacy of clinoptilolite preparations was investigated by administering DSS-treated mice twice daily with 30 mg GHC2 or GHC1 for 5 consecutive days, followed by 5 days of 2017-01-01T00:00:00Z2017 Dec2026-06-16T05:19:51.335Z2019-08-04T07:59:29ZS-EPMC61768972927249510.1093/ibd/izx042