biostudies-literature00630Grasset LMedical Research CouncilAlzheimer's Society490-497https://www.ebi.ac.uk/biostudies/studies/S-EPMC6178133biostudies-literatureUnknown10Introduction:The aims of this study are to examine the evolution of clinical dementia diagnosis over 3 decades and to investigate secular trends of dementia. Methods:Four cohorts covering a period from 1988 to 2013 were used: the Personnes Agées Quid and Three-City-Bordeaux studies, and the Cognitive Function and Aging Study (CFAS) I and II. Mini-Mental State Examination scores at clinical diagnosis were evaluated over a 24-year follow-up period in French studies. An algorithmic approach was applied to CFAS I and II to provide dementia prevalence and incidence estimates. Results:A significant increase of the Mini-Mental State Examination score at diagnosis was observed until 2000 and a significant decrease after. We reported a prevalence of 8.8% for CFAS I (1990-1993) compared with a prevalence of 6.5% in CFAS II (2008-2011). The 2-year incidence rate was estimated at 31.2/1000 (95% confidence interval = 28.0-34.8) for CFAS I and 15.0/1000 (95% confidence interval = 13.5-16.7) for CFAS II. Discussion:Applying a stable algorithm to different cohorts across time can provide a robust method for time trends estimation.Alzheimer's & dementia (Amsterdam, Netherlands)Evolution of dementia diagnosis over time (1988-2013): Evidence from French and English cohorts. Implication for secular trends analyses.PMC6178133MC_U105292687G9901400294Dartigues JFPeres KBrayne CMatthews FEFoubert-Samier AHelmer CGrasset L63falseEvolution of dementia diagnosis over time (1988-2013): Evidence from French and English cohorts. Implication for secular trends analyses.Introduction:The aims of this study are to examine the evolution of clinical dementia diagnosis over 3 decades and to investigate secular trends of dementia. Methods:Four cohorts covering a period from 1988 to 2013 were used: the Personnes Agées Quid and Three-City-Bordeaux studies, and the Cognitive Function and Aging Study (CFAS) I and II. Mini-Mental State Examination scores at clinical diagnosis were evaluated over a 24-year follow-up period in French studies. An algorithmic approach was applied to CFAS I and II to provide dementia prevalence and incidence estimates. Results:A significant increase of the Mini-Mental State Examination score at diagnosis was observed until 2000 and a significant decrease after. We reported a prevalence of 8.8% for CFAS I (1990-1993) compared with a prevalence of 6.5% in CFAS II (2008-2011). The 2-year incidence rate was estimated at 31.2/1000 (95% confidence interval = 28.0-34.8) for CFAS I and 15.0/1000 (95% confidence interval = 13.5-16.7) for CFAS II. Discussion:Applying a stable algorithm to different cohorts across time can provide a robust method for time trends estimation.2018-01-01T00:00:00Z20182021-02-20T12:09:15Z2019-03-27T00:14:32ZS-EPMC61781333031085110.1016/j.dadm.2018.07.005