biostudies-literatureHoppe SDeutsche Forschungsgemeinschaft719https://www.ebi.ac.uk/biostudies/studies/S-EPMC6182809biostudies-literatureUnknown11(1)<h4>Objective</h4>Chloride (Cl^-) secretion is crucial for intestinal fluid secretion. Therefore, effects of the polyphenol Resveratrol (RSV) on Cl^- secretion have been investigated. In a previous study, we observed effects of RSV on forskolin-induced Cl^- secretion in the porcine jejunum but not the ileum although RSV itself induced a transepithelial ion current that may represent Cl^- secretion in the ileum. The aim of this study was to gain further insights regarding the effects of RSV on characteristics of Cl^- secretion in the porcine ileum using the Ussing chamber technique (recording of short circuit currents (I_sc) as a measure for epithelial net ion transfer).<h4>Results</h4>RSV increased the I_sc in the porcinBMC research notesCalcium-induced chloride secretion is decreased by Resveratrol in ileal porcine tissue.PMC6182809KL 2882/2-1Hoppe SKlinger SBreves GfalseCalcium-induced chloride secretion is decreased by Resveratrol in ileal porcine tissue.<h4>Objective</h4>Chloride (Cl^-) secretion is crucial for intestinal fluid secretion. Therefore, effects of the polyphenol Resveratrol (RSV) on Cl^- secretion have been investigated. In a previous study, we observed effects of RSV on forskolin-induced Cl^- secretion in the porcine jejunum but not the ileum although RSV itself induced a transepithelial ion current that may represent Cl^- secretion in the ileum. The aim of this study was to gain further insights regarding the effects of RSV on characteristics of Cl^- secretion in the porcine ileum using the Ussing chamber technique (recording of short circuit currents (I_sc) as a measure for epithelial net ion transfer).<h4>Results</h4>RSV increased the I_sc in the porcin2018-01-01T00:00:00Z2018 Oct2025-04-22T06:45:28.411Z2019-03-27T00:02:43ZS-EPMC61828093030937410.1186/s13104-018-3825-4