biostudies-literatureUnknown12(6)Caini SSanofi Pasteur<h4>Aim</h4>Studies carried out in the early 2000s found that the number of influenza-associated hospitalizations and deaths was highest in seasons dominated by A(H3N2), suggesting that the clinical presentation and severity of influenza may differ across virus types, subtypes, and lineages. We aimed to review the studies that examined this hypothesis.<h4>Method</h4>We conducted a literature review of studies published until January 2017 that compared the clinical presentation, disease severity, and case-fatality ratio of influenza patients infected with different virus types (A, B), subtypes (pre-pandemic A(H1N1), A(H1N1)p, A(H3N2)), and lineages (Victoria, Yamagata).<h4>Results</h4>The literature search resulted in over 1700 entries: After applying in- and exclusion criteria, 47 studies Influenza and other respiratory viruses780-792https://www.ebi.ac.uk/biostudies/studies/S-EPMC6185883biostudies-literatureClinical characteristics and severity of influenza infections by virus type, subtype, and lineage: A systematic literature review.PMC6185883El Guerche-Seblain CCaini SKroneman MWiegers TPaget JfalseClinical characteristics and severity of influenza infections by virus type, subtype, and lineage: A systematic literature review.<h4>Aim</h4>Studies carried out in the early 2000s found that the number of influenza-associated hospitalizations and deaths was highest in seasons dominated by A(H3N2), suggesting that the clinical presentation and severity of influenza may differ across virus types, subtypes, and lineages. We aimed to review the studies that examined this hypothesis.<h4>Method</h4>We conducted a literature review of studies published until January 2017 that compared the clinical presentation, disease severity, and case-fatality ratio of influenza patients infected with different virus types (A, B), subtypes (pre-pandemic A(H1N1), A(H1N1)p, A(H3N2)), and lineages (Victoria, Yamagata).<h4>Results</h4>The literature search resulted in over 1700 entries: After applying in- and exclusion criteria, 47 studies 2018-01-01T00:00:00Z2018 Nov2025-04-22T06:42:56.969Z2019-03-27T00:05:09ZS-EPMC61858832985853710.1111/irv.12575