biostudies-literatureAbecia LBiotechnology and Biological Sciences Research CouncilInstituto Nacional de Investigación y Tecnología Agraria y Alimentaria2227https://www.ebi.ac.uk/biostudies/studies/S-EPMC6189281biostudies-literatureUnknown9This work aimed to gain insight into the transition from milk to solid feeding at weaning combining genomics and metabolomics on rumen contents from goat kids treated with a methanogenic inhibitor (bromochloromethane, BCM). Sixteen goats giving birth to two kids were used. Eight does were treated (D+) with BCM after giving birth and over 2 months. One kid per doe in both groups was treated with BCM (k+) for 3 months while the other was untreated (k-). Rumen samples were collected from kids at weaning (W) and 1 (W + 1) and 4 (W + 4) months after and from does at weaning and subjected to 16S pyrosequencing and metabolomics analyses combining GC/LC-MS. Results from pyrosequencing showed a clear effect of age of kids, with more diverse bacterial community as solid feed becomes more important aFrontiers in microbiologyAnalysis of the Rumen Microbiome and Metabolome to Study the Effect of an Antimethanogenic Treatment Applied in Early Life of Kid Goats.PMC6189281BBS/E/W/10964A01BBBS/OS/GC/000011BMartin-Garcia AIMartinez-Fernandez GWaddams KPinloche ENewbold CJYanez-Ruiz DRCreevey CJDenman SEAbecia LfalseAnalysis of the Rumen Microbiome and Metabolome to Study the Effect of an Antimethanogenic Treatment Applied in Early Life of Kid Goats.This work aimed to gain insight into the transition from milk to solid feeding at weaning combining genomics and metabolomics on rumen contents from goat kids treated with a methanogenic inhibitor (bromochloromethane, BCM). Sixteen goats giving birth to two kids were used. Eight does were treated (D+) with BCM after giving birth and over 2 months. One kid per doe in both groups was treated with BCM (k+) for 3 months while the other was untreated (k-). Rumen samples were collected from kids at weaning (W) and 1 (W + 1) and 4 (W + 4) months after and from does at weaning and subjected to 16S pyrosequencing and metabolomics analyses combining GC/LC-MS. Results from pyrosequencing showed a clear effect of age of kids, with more diverse bacterial community as solid feed becomes more important a2018-01-01T00:00:00Z20182026-05-01T01:44:15.557Z2019-03-27T00:03:56ZS-EPMC61892813035669010.3389/fmicb.2018.02227