biostudies-literatureUnknown18(1)Ren F<h4>Background</h4>Campylobacter jejuni (C. jejuni) is a leading cause of foodborne gastroenteritis worldwide. This bacterium lacks many of the classical virulence factors, and flagellum-associated persistent colonization has been shown to be crucial for its pathogenesis. The flagellum plays a multifunctional role in C. jejuni pathogenesis, and different flagellar elements make diverse contributions. The flhF gene encodes the flagellar biosynthesis regulator, which is important for flagellar biosynthesis. In this study, the influence of flhF on C. jejuni colonization was systematically studied, and the possible mechanisms were also analyzed.<h4>Results</h4>The flhF gene has a significant influence on C. jejuni colonization, and its inactivation resulted in severe defects in the commensal cBMC microbiology149https://www.ebi.ac.uk/biostudies/studies/S-EPMC6196472biostudies-literatureInsights into the impact of flhF inactivation on Campylobacter jejuni colonization of chick and mice gut.PMC6196472Li XRen FHuang JYun XJiang QLi QFang LTang YTang HHuang PJiao XAfalseInsights into the impact of flhF inactivation on Campylobacter jejuni colonization of chick and mice gut.<h4>Background</h4>Campylobacter jejuni (C. jejuni) is a leading cause of foodborne gastroenteritis worldwide. This bacterium lacks many of the classical virulence factors, and flagellum-associated persistent colonization has been shown to be crucial for its pathogenesis. The flagellum plays a multifunctional role in C. jejuni pathogenesis, and different flagellar elements make diverse contributions. The flhF gene encodes the flagellar biosynthesis regulator, which is important for flagellar biosynthesis. In this study, the influence of flhF on C. jejuni colonization was systematically studied, and the possible mechanisms were also analyzed.<h4>Results</h4>The flhF gene has a significant influence on C. jejuni colonization, and its inactivation resulted in severe defects in the commensal c2018-01-01T00:00:00Z2018 Oct2026-06-18T05:57:22.901Z2019-03-27T00:04:30ZS-EPMC61964723034809010.1186/s12866-018-1318-1