{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lacy ME"],"funding":["NIA NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","Patient-Centered Outcomes Research Institute","National Institute on Aging"],"pagination":["2339-2345"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6196833"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(11)"],"pubmed_abstract":["<h4>Objective</h4>Individuals with type 1 diabetes have experienced an increase in life expectancy, yet it is unknown what level of glycemic control is ideal for maintaining late-life brain health. We investigated the association of long-term glycemic control with dementia in older individuals with type 1 diabetes.<h4>Research design and methods</h4>We followed 3,433 members of a health care system with type 1 diabetes, aged ≥50 years, from 1996 to 2015. Repeated measurements of hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>), dementia diagnoses, and comorbidities were ascertained from health records. Cox proportional hazards models were fit to evaluate the association of time-varying glycemic exposure with dementia, with adjustment for age, sex, race/ethnicity, baseline health conditions, an"],"journal":["Diabetes care"],"pubmed_title":["Long-term Glycemic Control and Dementia Risk in Type 1 Diabetes."],"pmcid":["PMC6196833"],"funding_grant_id":["R01-DK-103721","PPRN-1306-04709","T32 AG049663","T32-AG-049663","P30-DK-092924","P30 AG010129","R01-DK-081796","R01-AG-047500","R01 AG047500"],"pubmed_authors":["Pletcher MJ","Quesenberry CP","Whitmer RA","Lacy ME","Gilsanz P","Karter AJ"],"additional_accession":[]},"is_claimable":false,"name":"Long-term Glycemic Control and Dementia Risk in Type 1 Diabetes.","description":"<h4>Objective</h4>Individuals with type 1 diabetes have experienced an increase in life expectancy, yet it is unknown what level of glycemic control is ideal for maintaining late-life brain health. We investigated the association of long-term glycemic control with dementia in older individuals with type 1 diabetes.<h4>Research design and methods</h4>We followed 3,433 members of a health care system with type 1 diabetes, aged ≥50 years, from 1996 to 2015. Repeated measurements of hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>), dementia diagnoses, and comorbidities were ascertained from health records. Cox proportional hazards models were fit to evaluate the association of time-varying glycemic exposure with dementia, with adjustment for age, sex, race/ethnicity, baseline health conditions, an","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2025-04-04T13:30:06.162Z","creation":"2019-11-07T08:01:37Z"},"accession":"S-EPMC6196833","cross_references":{"pubmed":["30181165"],"doi":["10.2337/dc18-0073"]}}