biostudies-literatureLacy MENIA NIH HHSNational Institute of Diabetes and Digestive and Kidney DiseasesPatient-Centered Outcomes Research InstituteNational Institute on Aging2339-2345https://www.ebi.ac.uk/biostudies/studies/S-EPMC6196833biostudies-literatureUnknown41(11)<h4>Objective</h4>Individuals with type 1 diabetes have experienced an increase in life expectancy, yet it is unknown what level of glycemic control is ideal for maintaining late-life brain health. We investigated the association of long-term glycemic control with dementia in older individuals with type 1 diabetes.<h4>Research design and methods</h4>We followed 3,433 members of a health care system with type 1 diabetes, aged ≥50 years, from 1996 to 2015. Repeated measurements of hemoglobin A_1c (HbA_1c), dementia diagnoses, and comorbidities were ascertained from health records. Cox proportional hazards models were fit to evaluate the association of time-varying glycemic exposure with dementia, with adjustment for age, sex, race/ethnicity, baseline health conditions, anDiabetes careLong-term Glycemic Control and Dementia Risk in Type 1 Diabetes.PMC6196833R01-DK-103721PPRN-1306-04709T32 AG049663T32-AG-049663P30-DK-092924P30 AG010129R01-DK-081796R01-AG-047500R01 AG047500Pletcher MJQuesenberry CPWhitmer RALacy MEGilsanz PKarter AJfalseLong-term Glycemic Control and Dementia Risk in Type 1 Diabetes.<h4>Objective</h4>Individuals with type 1 diabetes have experienced an increase in life expectancy, yet it is unknown what level of glycemic control is ideal for maintaining late-life brain health. We investigated the association of long-term glycemic control with dementia in older individuals with type 1 diabetes.<h4>Research design and methods</h4>We followed 3,433 members of a health care system with type 1 diabetes, aged ≥50 years, from 1996 to 2015. Repeated measurements of hemoglobin A_1c (HbA_1c), dementia diagnoses, and comorbidities were ascertained from health records. Cox proportional hazards models were fit to evaluate the association of time-varying glycemic exposure with dementia, with adjustment for age, sex, race/ethnicity, baseline health conditions, an2018-01-01T00:00:00Z2018 Nov2025-04-04T13:30:06.162Z2019-11-07T08:01:37ZS-EPMC61968333018116510.2337/dc18-0073