{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(10)"],"submitter":["Jitsumura M"],"funding":["Imperial Biomedical Research Centre","Pathway to Portfolio funding"],"pubmed_abstract":["<h4>Background</h4>The interaction of the gut microbiota with the human host is implicated in the pathogenesis of inflammatory and immunological diseases including ulcerative colitis (UC). Faecal microbiota transplantation (FMT) as a method of restoring gut microbial diversity is of increasing interest as a therapeutic approach in the management of UC. The current literature lacks consensus about the dose of FMT, route of administration and duration of response.<h4>Methods and analysis</h4>This single-blinded randomised trial will explore the feasibility of FMT in 30 treatment-naïve patients with histologically confirmed distal UC limited to the recto-sigmoid region (up to 40 cm from the anal verge). This study aims to estimate the magnitude of treatment response to FMT under controlled co"],"journal":["BMJ open"],"pagination":["e021987"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6196852"],"repository":["biostudies-literature"],"pubmed_title":["Protocol for faecal microbiota transplantation in ulcerative colitis (FMTUC): a randomised feasibility study."],"pmcid":["PMC6196852"],"pubmed_authors":["Hitchings MD","Islam S","Williams JG","Cunningham AL","Wilkinson TS","Harris DA","Kinross J","Jitsumura M","Row PE","Jenkins GJ","Riddell AD","Davies AP"],"additional_accession":[]},"is_claimable":false,"name":"Protocol for faecal microbiota transplantation in ulcerative colitis (FMTUC): a randomised feasibility study.","description":"<h4>Background</h4>The interaction of the gut microbiota with the human host is implicated in the pathogenesis of inflammatory and immunological diseases including ulcerative colitis (UC). Faecal microbiota transplantation (FMT) as a method of restoring gut microbial diversity is of increasing interest as a therapeutic approach in the management of UC. The current literature lacks consensus about the dose of FMT, route of administration and duration of response.<h4>Methods and analysis</h4>This single-blinded randomised trial will explore the feasibility of FMT in 30 treatment-naïve patients with histologically confirmed distal UC limited to the recto-sigmoid region (up to 40 cm from the anal verge). This study aims to estimate the magnitude of treatment response to FMT under controlled co","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Oct","modification":"2026-06-06T20:37:35.692Z","creation":"2019-03-27T00:04:10Z"},"accession":"S-EPMC6196852","cross_references":{"pubmed":["30341117"],"doi":["10.1136/bmjopen-2018-021987"]}}