biostudies-literatureUnknown8(10)Jitsumura MImperial Biomedical Research CentrePathway to Portfolio funding<h4>Background</h4>The interaction of the gut microbiota with the human host is implicated in the pathogenesis of inflammatory and immunological diseases including ulcerative colitis (UC). Faecal microbiota transplantation (FMT) as a method of restoring gut microbial diversity is of increasing interest as a therapeutic approach in the management of UC. The current literature lacks consensus about the dose of FMT, route of administration and duration of response.<h4>Methods and analysis</h4>This single-blinded randomised trial will explore the feasibility of FMT in 30 treatment-naïve patients with histologically confirmed distal UC limited to the recto-sigmoid region (up to 40 cm from the anal verge). This study aims to estimate the magnitude of treatment response to FMT under controlled coBMJ opene021987https://www.ebi.ac.uk/biostudies/studies/S-EPMC6196852biostudies-literatureProtocol for faecal microbiota transplantation in ulcerative colitis (FMTUC): a randomised feasibility study.PMC6196852Hitchings MDIslam SWilliams JGCunningham ALWilkinson TSHarris DAKinross JJitsumura MRow PEJenkins GJRiddell ADDavies APfalseProtocol for faecal microbiota transplantation in ulcerative colitis (FMTUC): a randomised feasibility study.<h4>Background</h4>The interaction of the gut microbiota with the human host is implicated in the pathogenesis of inflammatory and immunological diseases including ulcerative colitis (UC). Faecal microbiota transplantation (FMT) as a method of restoring gut microbial diversity is of increasing interest as a therapeutic approach in the management of UC. The current literature lacks consensus about the dose of FMT, route of administration and duration of response.<h4>Methods and analysis</h4>This single-blinded randomised trial will explore the feasibility of FMT in 30 treatment-naïve patients with histologically confirmed distal UC limited to the recto-sigmoid region (up to 40 cm from the anal verge). This study aims to estimate the magnitude of treatment response to FMT under controlled co2018-01-01T00:00:00Z2018 Oct2026-06-06T20:37:35.692Z2019-03-27T00:04:10ZS-EPMC61968523034111710.1136/bmjopen-2018-021987