biostudies-literatureRogers AWNIDCR NIH HHSNHLBI NIH HHSNational Institutes of HealthNIGMS NIH HHS1383-1390https://www.ebi.ac.uk/biostudies/studies/S-EPMC6199677biostudies-literatureUnknown97(12)Temporomandibular joint (TMJ) osteoarthritis (TMJOA) disrupts extracellular matrix (ECM) homeostasis, leading to cartilage degradation. Upregulated a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-5 leads to cleavage of its substrate aggrecan (Acan) and is considered a hallmark of TMJOA. However, most research on ADAMTS5-Acan turnover has focused on hyaline cartilage, not fibrocartilage, which comprises the TMJ. The mandibular condylar cartilage (MCC) of the TMJ is organized in zones, and chondrocytes are arranged in axial rows, yet the molecular mechanisms required to generate the MCC zonal architecture have not been elucidated. Here, we test the hypothesis that ADAMTS5 is required for development of the TMJ MCC. Adamts5^+/+ and Adamts5^-/- murinJournal of dental researchThe Zonal Architecture of the Mandibular Condyle Requires ADAMTS5.PMC6199677P30-NIGMS-103331RO1-HL-121382P30-GM-103342P30 GM103331R01 HL121382T32 DE017551T32-DE-017551Cisewski SEKern CBRogers AWfalseThe Zonal Architecture of the Mandibular Condyle Requires ADAMTS5.Temporomandibular joint (TMJ) osteoarthritis (TMJOA) disrupts extracellular matrix (ECM) homeostasis, leading to cartilage degradation. Upregulated a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-5 leads to cleavage of its substrate aggrecan (Acan) and is considered a hallmark of TMJOA. However, most research on ADAMTS5-Acan turnover has focused on hyaline cartilage, not fibrocartilage, which comprises the TMJ. The mandibular condylar cartilage (MCC) of the TMJ is organized in zones, and chondrocytes are arranged in axial rows, yet the molecular mechanisms required to generate the MCC zonal architecture have not been elucidated. Here, we test the hypothesis that ADAMTS5 is required for development of the TMJ MCC. Adamts5^+/+ and Adamts5^-/- murin2018-01-01T00:00:00Z2018 Nov2025-04-04T13:30:19.516Z2019-11-07T08:01:40ZS-EPMC61996772987937910.1177/0022034518777751