biostudies-literatureUnknown8(1)Wu YCComputed Tomography (CT) is a powerful method for non-destructive testing (NDT) and metrology awakes with expanding application fields. To improve the spatial resolution of high energy CT, a micro-spot gamma-ray source based on bremsstrahlung from a laser wakefield accelerator was developed. A high energy CT using the source was performed, which shows that the resolution of reconstruction can reach 100 μm at 10% contrast. Our proof-of-principle demonstration indicates that laser driven micro-spot gamma-ray sources provide a prospective way to increase the spatial resolution and toward to high energy micro CT. Due to the advantage in spatial resolution, laser based high energy CT represents a large potential for many NDT applications.Scientific reports15888https://www.ebi.ac.uk/biostudies/studies/S-EPMC6203838biostudies-literatureTowards high-energy, high-resolution computed tomography via a laser driven micro-spot gamma-ray source.PMC6203838Li GYan YHYang JFan WWang SYYu MHZhao ZQTan FLu FZhu BZhang XHWu YCYang YGu YQBi BDong KGCao LFZhou WMZhang TKfalseTowards high-energy, high-resolution computed tomography via a laser driven micro-spot gamma-ray source.Computed Tomography (CT) is a powerful method for non-destructive testing (NDT) and metrology awakes with expanding application fields. To improve the spatial resolution of high energy CT, a micro-spot gamma-ray source based on bremsstrahlung from a laser wakefield accelerator was developed. A high energy CT using the source was performed, which shows that the resolution of reconstruction can reach 100 μm at 10% contrast. Our proof-of-principle demonstration indicates that laser driven micro-spot gamma-ray sources provide a prospective way to increase the spatial resolution and toward to high energy micro CT. Due to the advantage in spatial resolution, laser based high energy CT represents a large potential for many NDT applications.2018-01-01T00:00:00Z2018 Oct2025-04-22T16:05:14.264Z2019-03-27T00:05:32ZS-EPMC62038383036709010.1038/s41598-018-33844-7